Left ventricular function after reversal of myocardial hypertrophy in systemic hypertension, and response to acute increase of afterload by cold pressor test

Anna Maria Grandi, Achille Venco, Andrea Bertolini, Paolo Pantaleo, Daniela Corbellini, Guido Perani, Pietro Folino, Giuseppe Gobbi, Giorgio Finardi

Research output: Contribution to journalArticle

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Abstract

Using digitized M-mode echocardragraphy, the left ventricular (LV) response to acute increase in blood pressure after regression of myocardial hypertrophy due to an effective antihypertensive treatment was evaluated. Fifteen hypertensive patients with basal LV hypertrophy (LV mass >230 g, and normal LV diastolic diameter) and normal LV mass after 3 to 4 months of treatment with angiotensin-converting enzyme inhibitors were selected for study. Subjects performed a cold pressor test before and after therapy. LV systolic function was normal in all subjects. LV diastolic function (impaired at basal evaluation in 13 subjects) improved after therapy in all subjects, with normalization in 10. Before treatment, the cold pressure and heart rate without changes in LV parameters. After regression of hypertrophy, the cold pressor test induced increases in hemodynamic parameters comparable to those of the basal test, and LV parameters remained unchanged. Our results indicate that regression of myocardial hypertrophy induced by angiotensin-converting enzyme inhibitors does not impair the ability of the left ventricle to face acute increases in after-load. The improvement in LV diastolic function (found at rest after reversal of hypertrophy) persists during the cold pressor test, which confirms that it is primarily due to LV mass reduction and is not simply a consequence of decrease in after-load induced by treatment.

Original languageEnglish
Pages (from-to)1439-1441
Number of pages3
JournalThe American Journal of Cardiology
Volume69
Issue number17
DOIs
Publication statusPublished - Jun 1 1992

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Left Ventricular Function
Hypertrophy
Hypertension
Angiotensin-Converting Enzyme Inhibitors
Therapeutics
Left Ventricular Hypertrophy
Antihypertensive Agents
Heart Ventricles
Heart Rate
Hemodynamics
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Left ventricular function after reversal of myocardial hypertrophy in systemic hypertension, and response to acute increase of afterload by cold pressor test. / Grandi, Anna Maria; Venco, Achille; Bertolini, Andrea; Pantaleo, Paolo; Corbellini, Daniela; Perani, Guido; Folino, Pietro; Gobbi, Giuseppe; Finardi, Giorgio.

In: The American Journal of Cardiology, Vol. 69, No. 17, 01.06.1992, p. 1439-1441.

Research output: Contribution to journalArticle

Grandi, Anna Maria ; Venco, Achille ; Bertolini, Andrea ; Pantaleo, Paolo ; Corbellini, Daniela ; Perani, Guido ; Folino, Pietro ; Gobbi, Giuseppe ; Finardi, Giorgio. / Left ventricular function after reversal of myocardial hypertrophy in systemic hypertension, and response to acute increase of afterload by cold pressor test. In: The American Journal of Cardiology. 1992 ; Vol. 69, No. 17. pp. 1439-1441.
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