Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency

Salvatore Longobardi, Alberto Cuocolo, Bartolomeo Merola, Francesca Di Rella, Annamaria Colao, Emanuele Nicolai, Stefania Cardei, Marco Salvatore, Gaetano Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: The impairment of heart structure and function in adults with childhood onset GH deficiency has been recently described. However, previous echocardiographic studies have reported no differences in cardiac mass and function between adulthood onset GH deficient patients and healthy subjects. DESIGN: The aim of this study was to evaluate cardiac performance In adult patients with childhood and adulthood onset GH deficiency, using equilibrium radionuclide angiography, a method more accurate than echocardiography. PATIENTS: Eleven patients with childhood onset GH deficiency, 9 patients with adulthood onset GH deficiency and 12 age-, gender-, height- and weight- matched healthy subjects entered the study. MEASUREMENTS: All the study population underwent equilibrium radionuclide angiography st rest and during physical exercise. RESULTS: Both childhood and adulthood onset GH deficient patients had an impaired left ventricular systolic performance both at rest (ejection fraction was 55 ± 6%, 55 ± 10% and 66 ± 6% in childhood and adulthood onset GH deficient patients and control group, respectively; P

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalClinical Endocrinology
Volume48
Issue number2
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Endocrinology

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