Left ventricular geometry, ambulatory blood pressure and extra-cardiac organ damage in untreated essential hypertension

Cesare Cuspidi, Valentina Giudici, Francesca Negri, Carla Sala, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aim: Limited information is available on the association between left ventricular (LV) geometric patterns defined according to updated criteria and blood pressure (BP) levels and extra-cardiac organ damage (OD) in human hypertension. Thus, in untreated essential hypertensives we assessed the relationship between LV geometry, ambulatory BP and markers of vascular and renal OD. Methods: A total of 669 hypertensives were categorized in four groups according to LV geometric patterns defined by two sets of sex-specific criteria (i.e. LV mass indexed to body surface area and height) and by the relative wall thickness (RWT) partition value of 0.42. Ambulatory BP variables were derived from two 24-h monitoring sessions performed within 4 weeks. Results: Lower clinic and ambulatory BP values were associated with normal LV geometry, intermediate values with either LV concentric remodelling or eccentric LV hypertrophy (LVH) and higher values with concentric LVH, regardless of the criteria used to categorize these cardiac phenotypes. A decrease in nocturnal BP dip occurred from normal LV geometry to concentric LVH and this was associated with a parallel increase in the prevalence of carotid and renal OD, which was highest in concentric LVH. In a multivariate analysis age (β=0.204, P

Original languageEnglish
Pages (from-to)124-131
Number of pages8
JournalBlood Pressure Monitoring
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Ambulatory blood pressure
  • Concentric geometry
  • Extra-cardiac organ damage

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing

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