Left ventricular hypertrophy and impaired diastolic filling in essential hypertension: Diastolic mechanisms for systolic dysfunction during exercise

Alberto Cuocolo, Frederick L. Sax, John E. Brush, Barry J. Maron, Stephen L. Bacharach, Robert O. Bonow

Research output: Contribution to journalArticlepeer-review

Abstract

Left ventricular ejection fraction is normal at rest but may respond abnormally to exercise in many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fraction either increased by less than 5% or decreased with exercise. Left ventricular diastolic filling was impaired at rest in patients in group 2 compared with group 1, with reduced peak filling rate (2.5±0.4 vs. 3.1±0.7 end-diastolic volume/sec; p2;p

Original languageEnglish
Pages (from-to)978-986
Number of pages9
JournalCirculation
Volume81
Issue number3
Publication statusPublished - Mar 1990

Keywords

  • Essential hypertension
  • Left ventricular function
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Left ventricular hypertrophy and impaired diastolic filling in essential hypertension: Diastolic mechanisms for systolic dysfunction during exercise'. Together they form a unique fingerprint.

Cite this