Left ventricular hypertrophy and impaired diastolic filling in essential hypertension: Diastolic mechanisms for systolic dysfunction during exercise

Alberto Cuocolo; Frederick L. Sax; John E. Brush; Barry J. Maron; Stephen L. Bacharach; Robert O. Bonow

Left ventricular hypertrophy and impaired diastolic filling in essential hypertension: Diastolic mechanisms for systolic dysfunction during exercise

Alberto Cuocolo, Frederick L. Sax, John E. Brush, Barry J. Maron, Stephen L. Bacharach, Robert O. Bonow

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Research output: Contribution to journal › Article › peer-review

Abstract

Left ventricular ejection fraction is normal at rest but may respond abnormally to exercise in many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fraction either increased by less than 5% or decreased with exercise. Left ventricular diastolic filling was impaired at rest in patients in group 2 compared with group 1, with reduced peak filling rate (2.5±0.4 vs. 3.1±0.7 end-diastolic volume/sec; p2;p

Original language	English
Pages (from-to)	978-986
Number of pages	9
Journal	Circulation
Volume	81
Issue number	3
Publication status	Published - Mar 1990

Keywords

Essential hypertension
Left ventricular function
Left ventricular hypertrophy

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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Left ventricular hypertrophy and impaired diastolic filling in essential hypertension : Diastolic mechanisms for systolic dysfunction during exercise. / Cuocolo, Alberto; Sax, Frederick L.; Brush, John E.; Maron, Barry J.; Bacharach, Stephen L.; Bonow, Robert O.

In: Circulation, Vol. 81, No. 3, 03.1990, p. 978-986.

Research output: Contribution to journal › Article › peer-review

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