TY - JOUR
T1 - Left ventricular hypertrophy and impaired diastolic filling in essential hypertension
T2 - Diastolic mechanisms for systolic dysfunction during exercise
AU - Cuocolo, Alberto
AU - Sax, Frederick L.
AU - Brush, John E.
AU - Maron, Barry J.
AU - Bacharach, Stephen L.
AU - Bonow, Robert O.
PY - 1990/3
Y1 - 1990/3
N2 - Left ventricular ejection fraction is normal at rest but may respond abnormally to exercise in many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fraction either increased by less than 5% or decreased with exercise. Left ventricular diastolic filling was impaired at rest in patients in group 2 compared with group 1, with reduced peak filling rate (2.5±0.4 vs. 3.1±0.7 end-diastolic volume/sec; p2;p
AB - Left ventricular ejection fraction is normal at rest but may respond abnormally to exercise in many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fraction either increased by less than 5% or decreased with exercise. Left ventricular diastolic filling was impaired at rest in patients in group 2 compared with group 1, with reduced peak filling rate (2.5±0.4 vs. 3.1±0.7 end-diastolic volume/sec; p2;p
KW - Essential hypertension
KW - Left ventricular function
KW - Left ventricular hypertrophy
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M3 - Article
C2 - 2137735
AN - SCOPUS:0025275866
VL - 81
SP - 978
EP - 986
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -