Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients

Giulio Selvetella, Antonella Notte, Angelo Maffei, Valentina Calistri, Virginia Scamardella, Giacomo Frati, Bruno Trimarco, Claudio Colonnese, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review


Background and Purpose - It has been demonstrated that left ventricular hypertrophy (LVH) confers an increased risk for major cerebrovascular events. However, it is still uncertain whether there is an association between LVH and asymptomatic cerebrovascular damage in hypertensive patients. In this study, we investigated the relation between LVH, evaluated by both echocardiography (Echo-LVH) and electrocardiography (ECG-LVH), and preclinical cerebral damage, as identified by magnetic resonance imaging. Methods - One hundred ninety-five consecutive patients were enrolled in the study. We evaluated other risk factors such as age, sex, presence of diabetes, cholesterol levels, smoking status, heart rate, and systolic and diastolic blood pressure. Asymptomatic cerebrovascular damage was considered silent cerebral lesions: punctate lesions, lacunes, and territorial lesions. Patients were divided into 2 groups according to the presence of asymptomatic brain lesions. Results - The 2 groups of patients differed only in terms of age and systolic pressure. More importantly, the prevalence of Echo-LVH (83% versus 47.7%, P

Original languageEnglish
Pages (from-to)1766-1770
Number of pages5
Issue number7
Publication statusPublished - Jul 1 2003


  • Cerebral infarction
  • Electrocardiography
  • Hypertension
  • Magnetic resonance imaging
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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