Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure

Angelo Scuteri; Roberta Coluccia; Lorenzo Castello; Edoardo Nevola; Anna Maria Brancati; Massimo Volpe

doi:10.1093/eurheartj/ehp133

Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure

Angelo Scuteri, Roberta Coluccia, Lorenzo Castello, Edoardo Nevola, Anna Maria Brancati, Massimo Volpe

Research output: Contribution to journal › Article › peer-review

Abstract

AimsLeft ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels.Methods and resultsFour hundred subjects (mean age 79 ± 6 years) were studied. Left ventricular mass was measured echocardiographically in accordance with American Society of Echocardiography and normalized for body height to the 2.7 (LVMI). Global cognitive function was evaluated with the mini-mental state examination (MMSE) (maximum score 30). Dementia was defined as an MMSE score ®. Prevalence of hypertension was 70 and diabetes mellitus was diagnosed in 25. No significant differences in traditional CV risk factors were observed across LVMI quartiles. Mini-mental state examination showed an inverse trend across LVMI quartiles (the higher the LVMI, the lower the MMSE, P for trend

Original language	English
Pages (from-to)	1525-1529
Number of pages	5
Journal	European Heart Journal
Volume	30
Issue number	12
DOIs	https://doi.org/10.1093/eurheartj/ehp133
Publication status	Published - Jun 2009

Keywords

Arterial stiffness
Blood pressure
Cognition
Dementia
Elderly
Left ventricular mass
Pulse wave velocity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1093/eurheartj/ehp133

Fingerprint Dive into the research topics of 'Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure'. Together they form a unique fingerprint.

Cite this

Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure. / Scuteri, Angelo; Coluccia, Roberta; Castello, Lorenzo; Nevola, Edoardo; Brancati, Anna Maria; Volpe, Massimo.

In: European Heart Journal, Vol. 30, No. 12, 06.2009, p. 1525-1529.

Research output: Contribution to journal › Article › peer-review

@article{14d25d18c78d47fd99f2fb44cc0730e3,

title = "Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure",

abstract = "AimsLeft ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels.Methods and resultsFour hundred subjects (mean age 79 ± 6 years) were studied. Left ventricular mass was measured echocardiographically in accordance with American Society of Echocardiography and normalized for body height to the 2.7 (LVMI). Global cognitive function was evaluated with the mini-mental state examination (MMSE) (maximum score 30). Dementia was defined as an MMSE score {\textregistered}. Prevalence of hypertension was 70 and diabetes mellitus was diagnosed in 25. No significant differences in traditional CV risk factors were observed across LVMI quartiles. Mini-mental state examination showed an inverse trend across LVMI quartiles (the higher the LVMI, the lower the MMSE, P for trend ",

keywords = "Arterial stiffness, Blood pressure, Cognition, Dementia, Elderly, Left ventricular mass, Pulse wave velocity",

author = "Angelo Scuteri and Roberta Coluccia and Lorenzo Castello and Edoardo Nevola and Brancati, {Anna Maria} and Massimo Volpe",

year = "2009",

month = jun,

doi = "10.1093/eurheartj/ehp133",

language = "English",

volume = "30",

pages = "1525--1529",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure

AU - Scuteri, Angelo

AU - Coluccia, Roberta

AU - Castello, Lorenzo

AU - Nevola, Edoardo

AU - Brancati, Anna Maria

AU - Volpe, Massimo

PY - 2009/6

Y1 - 2009/6

N2 - AimsLeft ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels.Methods and resultsFour hundred subjects (mean age 79 ± 6 years) were studied. Left ventricular mass was measured echocardiographically in accordance with American Society of Echocardiography and normalized for body height to the 2.7 (LVMI). Global cognitive function was evaluated with the mini-mental state examination (MMSE) (maximum score 30). Dementia was defined as an MMSE score ®. Prevalence of hypertension was 70 and diabetes mellitus was diagnosed in 25. No significant differences in traditional CV risk factors were observed across LVMI quartiles. Mini-mental state examination showed an inverse trend across LVMI quartiles (the higher the LVMI, the lower the MMSE, P for trend

AB - AimsLeft ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels.Methods and resultsFour hundred subjects (mean age 79 ± 6 years) were studied. Left ventricular mass was measured echocardiographically in accordance with American Society of Echocardiography and normalized for body height to the 2.7 (LVMI). Global cognitive function was evaluated with the mini-mental state examination (MMSE) (maximum score 30). Dementia was defined as an MMSE score ®. Prevalence of hypertension was 70 and diabetes mellitus was diagnosed in 25. No significant differences in traditional CV risk factors were observed across LVMI quartiles. Mini-mental state examination showed an inverse trend across LVMI quartiles (the higher the LVMI, the lower the MMSE, P for trend

KW - Arterial stiffness

KW - Blood pressure

KW - Cognition

KW - Dementia

KW - Elderly

KW - Left ventricular mass

KW - Pulse wave velocity

UR - http://www.scopus.com/inward/record.url?scp=67651094144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651094144&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehp133

DO - 10.1093/eurheartj/ehp133

M3 - Article

C2 - 19406864

AN - SCOPUS:67651094144

VL - 30

SP - 1525

EP - 1529

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 12

ER -

Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this