Abstract
Objective To determine a simplified method to identify presence of left ventricular hypertrophy (LVH) in pediatric populations because the relationship between heart growth and body growth in children has made indexing difficult for younger ages. Study design Healthy children (n = 400; 52% boys, 0-18 years of age) from 2 different European hospitals were studied to derive a simplified formula. Left ventricular mass (LVM) was calculated according to the Devereux formula. The derived approach to index LVM was tested on a validation cohort of 130 healthy children from a different hospital center. Results There was a strong nonlinear correlation between height and LVM. LVM was best related to height to a power of 2.16 with a correction factor of 0.09. Analysis of residuals for LVM/[(height2.16) + 0.09] showed an homoscedastic distribution in both sexes throughout the entire height range. A partition value of 45 g/m2.16 was defined as the upper normal limit for LVM index. As opposed to formula suggested by current guidelines (ie, LVM/height2.7) when applying the proposed approach in the validation cohort of 130 healthy participants, no false positives for LVH were found (0% vs 8%; P 2.16) value across the whole pediatric age range to identify LVH, without the time-consuming need of computing specific percentiles for height and sex.
| Original language | English |
|---|---|
| Pages (from-to) | 193-198 |
| Number of pages | 6 |
| Journal | Journal of Pediatrics |
| Volume | 170 |
| DOIs | |
| Publication status | Published - Mar 1 2016 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Left Ventricular Mass Indexing in Infants, Children, and Adolescents : A Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical Practice. / Chinali, Marcello; Emma, Francesco; Esposito, Claudia; Rinelli, Gabriele; Franceschini, Alessio; Doyon, Anke; Raimondi, Francesca; Pongiglione, Giacomo; Schaefer, Franz; Matteucci, Maria Chiara.
In: Journal of Pediatrics, Vol. 170, 01.03.2016, p. 193-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Left Ventricular Mass Indexing in Infants, Children, and Adolescents
T2 - A Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical Practice
AU - Chinali, Marcello
AU - Emma, Francesco
AU - Esposito, Claudia
AU - Rinelli, Gabriele
AU - Franceschini, Alessio
AU - Doyon, Anke
AU - Raimondi, Francesca
AU - Pongiglione, Giacomo
AU - Schaefer, Franz
AU - Matteucci, Maria Chiara
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective To determine a simplified method to identify presence of left ventricular hypertrophy (LVH) in pediatric populations because the relationship between heart growth and body growth in children has made indexing difficult for younger ages. Study design Healthy children (n = 400; 52% boys, 0-18 years of age) from 2 different European hospitals were studied to derive a simplified formula. Left ventricular mass (LVM) was calculated according to the Devereux formula. The derived approach to index LVM was tested on a validation cohort of 130 healthy children from a different hospital center. Results There was a strong nonlinear correlation between height and LVM. LVM was best related to height to a power of 2.16 with a correction factor of 0.09. Analysis of residuals for LVM/[(height2.16) + 0.09] showed an homoscedastic distribution in both sexes throughout the entire height range. A partition value of 45 g/m2.16 was defined as the upper normal limit for LVM index. As opposed to formula suggested by current guidelines (ie, LVM/height2.7) when applying the proposed approach in the validation cohort of 130 healthy participants, no false positives for LVH were found (0% vs 8%; P 2.16) value across the whole pediatric age range to identify LVH, without the time-consuming need of computing specific percentiles for height and sex.
AB - Objective To determine a simplified method to identify presence of left ventricular hypertrophy (LVH) in pediatric populations because the relationship between heart growth and body growth in children has made indexing difficult for younger ages. Study design Healthy children (n = 400; 52% boys, 0-18 years of age) from 2 different European hospitals were studied to derive a simplified formula. Left ventricular mass (LVM) was calculated according to the Devereux formula. The derived approach to index LVM was tested on a validation cohort of 130 healthy children from a different hospital center. Results There was a strong nonlinear correlation between height and LVM. LVM was best related to height to a power of 2.16 with a correction factor of 0.09. Analysis of residuals for LVM/[(height2.16) + 0.09] showed an homoscedastic distribution in both sexes throughout the entire height range. A partition value of 45 g/m2.16 was defined as the upper normal limit for LVM index. As opposed to formula suggested by current guidelines (ie, LVM/height2.7) when applying the proposed approach in the validation cohort of 130 healthy participants, no false positives for LVH were found (0% vs 8%; P 2.16) value across the whole pediatric age range to identify LVH, without the time-consuming need of computing specific percentiles for height and sex.
UR - http://www.scopus.com/inward/record.url?scp=84971284009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971284009&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2015.10.085
DO - 10.1016/j.jpeds.2015.10.085
M3 - Article
C2 - 26670053
AN - SCOPUS:84971284009
VL - 170
SP - 193
EP - 198
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
ER -