Abstract
Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been described in some but not all patients with EH. Moreover, ouabain has a hypertrophic influence on isolated cardiac myocytes. Accordingly, we investigated relationships among plasma OLF, left ventricular mass, and cardiac function in patients with EH. Plasma OLF was determined in 110 normotensive subjects and 128 patients with EH. Echocardiographic parameters and humoral determinants were measured in EH. Plasma OLF levels were increased (P2, P=0.0003, and 57.10±1.48 versus 52.30±1.14 mL/m2, P=0.02, respectively), although heart rate was slower (74.2±1.3 versus 80.5±1.3 bpm, P=0.005). Multiple regression analysis that tested the influence of body mass index, age, gender, 24-hour blood pressure, and OLF on left ventricular mass revealed independent contributions of systolic (13.2%) and diastolic (12.4%) blood pressure and plasma OLF (11.6%) to left ventricular mass. We conclude that ≃50% of patients with uncomplicated EH have elevated-high circulating OLF levels, higher diastolic blood pressure, greater left ventricular mass and stroke volume, and reduced heart rate. We propose that the OLF affects cardiovascular function and structure and should be considered as a factor that contributes to the risk of morbid events.
| Original language | English |
|---|---|
| Pages (from-to) | 450-456 |
| Number of pages | 7 |
| Journal | Hypertension |
| Volume | 34 |
| Issue number | 3 |
| Publication status | Published - 1999 |
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Keywords
- Cardiac glycosides
- Digoxin
- Heart
- Human
- Hypertension, essential
- Sodium
- Sodium-potassium pump
ASJC Scopus subject areas
- Internal Medicine
Cite this
Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension. / Manunta, Paolo; Stella, Paola; Rivera, Rodolfo; Ciurlino, Daniele; Cusi, Daniele; Ferrandi, Mara; Hamlyn, John M.; Bianchi, Giuseppe.
In: Hypertension, Vol. 34, No. 3, 1999, p. 450-456.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension
AU - Manunta, Paolo
AU - Stella, Paola
AU - Rivera, Rodolfo
AU - Ciurlino, Daniele
AU - Cusi, Daniele
AU - Ferrandi, Mara
AU - Hamlyn, John M.
AU - Bianchi, Giuseppe
PY - 1999
Y1 - 1999
N2 - Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been described in some but not all patients with EH. Moreover, ouabain has a hypertrophic influence on isolated cardiac myocytes. Accordingly, we investigated relationships among plasma OLF, left ventricular mass, and cardiac function in patients with EH. Plasma OLF was determined in 110 normotensive subjects and 128 patients with EH. Echocardiographic parameters and humoral determinants were measured in EH. Plasma OLF levels were increased (P2, P=0.0003, and 57.10±1.48 versus 52.30±1.14 mL/m2, P=0.02, respectively), although heart rate was slower (74.2±1.3 versus 80.5±1.3 bpm, P=0.005). Multiple regression analysis that tested the influence of body mass index, age, gender, 24-hour blood pressure, and OLF on left ventricular mass revealed independent contributions of systolic (13.2%) and diastolic (12.4%) blood pressure and plasma OLF (11.6%) to left ventricular mass. We conclude that ≃50% of patients with uncomplicated EH have elevated-high circulating OLF levels, higher diastolic blood pressure, greater left ventricular mass and stroke volume, and reduced heart rate. We propose that the OLF affects cardiovascular function and structure and should be considered as a factor that contributes to the risk of morbid events.
AB - Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been described in some but not all patients with EH. Moreover, ouabain has a hypertrophic influence on isolated cardiac myocytes. Accordingly, we investigated relationships among plasma OLF, left ventricular mass, and cardiac function in patients with EH. Plasma OLF was determined in 110 normotensive subjects and 128 patients with EH. Echocardiographic parameters and humoral determinants were measured in EH. Plasma OLF levels were increased (P2, P=0.0003, and 57.10±1.48 versus 52.30±1.14 mL/m2, P=0.02, respectively), although heart rate was slower (74.2±1.3 versus 80.5±1.3 bpm, P=0.005). Multiple regression analysis that tested the influence of body mass index, age, gender, 24-hour blood pressure, and OLF on left ventricular mass revealed independent contributions of systolic (13.2%) and diastolic (12.4%) blood pressure and plasma OLF (11.6%) to left ventricular mass. We conclude that ≃50% of patients with uncomplicated EH have elevated-high circulating OLF levels, higher diastolic blood pressure, greater left ventricular mass and stroke volume, and reduced heart rate. We propose that the OLF affects cardiovascular function and structure and should be considered as a factor that contributes to the risk of morbid events.
KW - Cardiac glycosides
KW - Digoxin
KW - Heart
KW - Human
KW - Hypertension, essential
KW - Sodium
KW - Sodium-potassium pump
UR - http://www.scopus.com/inward/record.url?scp=0032886736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032886736&partnerID=8YFLogxK
M3 - Article
C2 - 10489392
AN - SCOPUS:0032886736
VL - 34
SP - 450
EP - 456
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 3
ER -