Abstract
Pulsed tissue Doppler (TD) is a new ultrasound tool that allows quantification of myocardial regional wall motion. To investigate the cardiac effects of subclinical hypothyroidism (SH), the present study assessed left ventricular (LV) myocardial regional function in SH by pulsed TD. Twenty women with SH and 20 healthy women underwent standard Doppler echocardiograms and pulsed TD, placing a sample volume at the level of posterior septum and LV mitral annulus. Myocardial systolic and diastolic velocities and time intervals were determined for both levels. Doppler-echocardiographic and TD measurements were adjusted for body surface area and heart rate. Standard Doppler showed an increases in LV preejection period, preejection period/LV ejection time ratio, and isovolumic relaxation time (IVRT) in SH. By TD analysis, myocardial precontraction time (PCTm), PCTm/myocardial contraction time ratio, and myocardial relaxation time (RTm) were prolonged at the level of both posterior septum and mitral annulus in SH. In the whole population, IVRT, PCTm, and RTm were negatively related to FT4, whereas IVRT, PCTm/ myocardial contraction time ratio, and RTm were positively correlated to TSH. In conclusion, this study underscores the usefulness of TD to detect cardiac functional abnormalities due to stable SH, mainly by changes in myocardial time intervals in several LV segments.
| Original language | English |
|---|---|
| Pages (from-to) | 4350-4355 |
| Number of pages | 6 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 87 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool : Pulsed tissue doppler. / Vitale, Giovanni; Galderisi, Maurizio; Lupoli, Gelsy Arianna; Celentano, Aldo; Pietropaolo, Ilaria; Parenti, Nicola; De Divitiis, Oreste; Lupoli, Giovanni.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 87, No. 9, 09.2002, p. 4350-4355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool
T2 - Pulsed tissue doppler
AU - Vitale, Giovanni
AU - Galderisi, Maurizio
AU - Lupoli, Gelsy Arianna
AU - Celentano, Aldo
AU - Pietropaolo, Ilaria
AU - Parenti, Nicola
AU - De Divitiis, Oreste
AU - Lupoli, Giovanni
PY - 2002/9
Y1 - 2002/9
N2 - Pulsed tissue Doppler (TD) is a new ultrasound tool that allows quantification of myocardial regional wall motion. To investigate the cardiac effects of subclinical hypothyroidism (SH), the present study assessed left ventricular (LV) myocardial regional function in SH by pulsed TD. Twenty women with SH and 20 healthy women underwent standard Doppler echocardiograms and pulsed TD, placing a sample volume at the level of posterior septum and LV mitral annulus. Myocardial systolic and diastolic velocities and time intervals were determined for both levels. Doppler-echocardiographic and TD measurements were adjusted for body surface area and heart rate. Standard Doppler showed an increases in LV preejection period, preejection period/LV ejection time ratio, and isovolumic relaxation time (IVRT) in SH. By TD analysis, myocardial precontraction time (PCTm), PCTm/myocardial contraction time ratio, and myocardial relaxation time (RTm) were prolonged at the level of both posterior septum and mitral annulus in SH. In the whole population, IVRT, PCTm, and RTm were negatively related to FT4, whereas IVRT, PCTm/ myocardial contraction time ratio, and RTm were positively correlated to TSH. In conclusion, this study underscores the usefulness of TD to detect cardiac functional abnormalities due to stable SH, mainly by changes in myocardial time intervals in several LV segments.
AB - Pulsed tissue Doppler (TD) is a new ultrasound tool that allows quantification of myocardial regional wall motion. To investigate the cardiac effects of subclinical hypothyroidism (SH), the present study assessed left ventricular (LV) myocardial regional function in SH by pulsed TD. Twenty women with SH and 20 healthy women underwent standard Doppler echocardiograms and pulsed TD, placing a sample volume at the level of posterior septum and LV mitral annulus. Myocardial systolic and diastolic velocities and time intervals were determined for both levels. Doppler-echocardiographic and TD measurements were adjusted for body surface area and heart rate. Standard Doppler showed an increases in LV preejection period, preejection period/LV ejection time ratio, and isovolumic relaxation time (IVRT) in SH. By TD analysis, myocardial precontraction time (PCTm), PCTm/myocardial contraction time ratio, and myocardial relaxation time (RTm) were prolonged at the level of both posterior septum and mitral annulus in SH. In the whole population, IVRT, PCTm, and RTm were negatively related to FT4, whereas IVRT, PCTm/ myocardial contraction time ratio, and RTm were positively correlated to TSH. In conclusion, this study underscores the usefulness of TD to detect cardiac functional abnormalities due to stable SH, mainly by changes in myocardial time intervals in several LV segments.
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U2 - 10.1210/jc.2002-011764
DO - 10.1210/jc.2002-011764
M3 - Article
VL - 87
SP - 4350
EP - 4355
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 9
ER -