Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool

Pulsed tissue doppler

Giovanni Vitale, Maurizio Galderisi, Gelsy Arianna Lupoli, Aldo Celentano, Ilaria Pietropaolo, Nicola Parenti, Oreste De Divitiis, Giovanni Lupoli

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Pulsed tissue Doppler (TD) is a new ultrasound tool that allows quantification of myocardial regional wall motion. To investigate the cardiac effects of subclinical hypothyroidism (SH), the present study assessed left ventricular (LV) myocardial regional function in SH by pulsed TD. Twenty women with SH and 20 healthy women underwent standard Doppler echocardiograms and pulsed TD, placing a sample volume at the level of posterior septum and LV mitral annulus. Myocardial systolic and diastolic velocities and time intervals were determined for both levels. Doppler-echocardiographic and TD measurements were adjusted for body surface area and heart rate. Standard Doppler showed an increases in LV preejection period, preejection period/LV ejection time ratio, and isovolumic relaxation time (IVRT) in SH. By TD analysis, myocardial precontraction time (PCTm), PCTm/myocardial contraction time ratio, and myocardial relaxation time (RTm) were prolonged at the level of both posterior septum and mitral annulus in SH. In the whole population, IVRT, PCTm, and RTm were negatively related to FT4, whereas IVRT, PCTm/ myocardial contraction time ratio, and RTm were positively correlated to TSH. In conclusion, this study underscores the usefulness of TD to detect cardiac functional abnormalities due to stable SH, mainly by changes in myocardial time intervals in several LV segments.

Original languageEnglish
Pages (from-to)4350-4355
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume87
Issue number9
DOIs
Publication statusPublished - Sep 2002

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Hypothyroidism
Relaxation time
Ultrasonics
Tissue
Myocardial Contraction
Ultrasonic Waves
Ventricular Septum
Body Surface Area

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool : Pulsed tissue doppler. / Vitale, Giovanni; Galderisi, Maurizio; Lupoli, Gelsy Arianna; Celentano, Aldo; Pietropaolo, Ilaria; Parenti, Nicola; De Divitiis, Oreste; Lupoli, Giovanni.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 87, No. 9, 09.2002, p. 4350-4355.

Research output: Contribution to journalArticle

Vitale, Giovanni ; Galderisi, Maurizio ; Lupoli, Gelsy Arianna ; Celentano, Aldo ; Pietropaolo, Ilaria ; Parenti, Nicola ; De Divitiis, Oreste ; Lupoli, Giovanni. / Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool : Pulsed tissue doppler. In: Journal of Clinical Endocrinology and Metabolism. 2002 ; Vol. 87, No. 9. pp. 4350-4355.
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