Left ventricular pacing with a new quadripolar transvenous lead for CRT: Early results of a prospective comparison with conventional implant outcomes

Giovanni B. Forleo, Domenico G. Della Rocca, Lida P. Papavasileiou, Arianna Di Molfetta, Luca Santini, Francesco Romeo

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background Flexible left ventricular (LV) pacing configurations are a useful component of cardiac resynchronization therapy (CRT) systems for preventing high LV pacing thresholds and phrenic nerve stimulation (PNS). A quadripolar LV lead has recently been designed with the purpose of allowing more choices in lead placement location and programming capability. Objective To verify the effectiveness of quadripolar LV leads compared to conventional bipolar LV leads implant outcomes. Methods Forty-five consecutive patients underwent implantation with either the quadripolar (n = 22; quadripolar group) or a conventional bipolar LV lead (n = 23; bipolar group). The primary outcome of the study was LV lead failure, defined as the need for lead revision or reprogramming during the first 3 months after implantation. Additionally, operative and follow-up data were prospectively noted and checked for significance between groups. Results The implantation success rate in both groups was 100%. Baseline characteristics, procedure duration, and fluoroscopy time did not differ significantly between groups. Two lead dislodgments (requiring reoperation) and 4 clinical PNS were reported in the bipolar group; reprogramming of the device was sufficient to prevent PNS in 3 patients, the fourth is pending solution. One PNS successfully managed noninvasively occurred in the quadripolar group. By Kaplan-Meier analysis, event-free survival for the combined primary outcome was significantly lower in patients with quadripolar leads (P = .037). Conclusion This prospective, controlled study provides strong evidence that CRT with the quadripolar LV lead results in low rates of dislocations and phrenic nerve stimulation.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalHeart Rhythm
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Cardiac Resynchronization Therapy
Phrenic Nerve
Fluoroscopy
Kaplan-Meier Estimate
Reoperation
Disease-Free Survival
Lead
Outcome Assessment (Health Care)
Prospective Studies
Equipment and Supplies

Keywords

  • Cardiac resynchronization therapy
  • Lead performance
  • Left ventricular lead
  • Left ventricular pacing configurations
  • Phrenic nerve stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Left ventricular pacing with a new quadripolar transvenous lead for CRT : Early results of a prospective comparison with conventional implant outcomes. / Forleo, Giovanni B.; Della Rocca, Domenico G.; Papavasileiou, Lida P.; Molfetta, Arianna Di; Santini, Luca; Romeo, Francesco.

In: Heart Rhythm, Vol. 8, No. 1, 01.2011, p. 31-37.

Research output: Contribution to journalArticle

Forleo, Giovanni B. ; Della Rocca, Domenico G. ; Papavasileiou, Lida P. ; Molfetta, Arianna Di ; Santini, Luca ; Romeo, Francesco. / Left ventricular pacing with a new quadripolar transvenous lead for CRT : Early results of a prospective comparison with conventional implant outcomes. In: Heart Rhythm. 2011 ; Vol. 8, No. 1. pp. 31-37.
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N2 - Background Flexible left ventricular (LV) pacing configurations are a useful component of cardiac resynchronization therapy (CRT) systems for preventing high LV pacing thresholds and phrenic nerve stimulation (PNS). A quadripolar LV lead has recently been designed with the purpose of allowing more choices in lead placement location and programming capability. Objective To verify the effectiveness of quadripolar LV leads compared to conventional bipolar LV leads implant outcomes. Methods Forty-five consecutive patients underwent implantation with either the quadripolar (n = 22; quadripolar group) or a conventional bipolar LV lead (n = 23; bipolar group). The primary outcome of the study was LV lead failure, defined as the need for lead revision or reprogramming during the first 3 months after implantation. Additionally, operative and follow-up data were prospectively noted and checked for significance between groups. Results The implantation success rate in both groups was 100%. Baseline characteristics, procedure duration, and fluoroscopy time did not differ significantly between groups. Two lead dislodgments (requiring reoperation) and 4 clinical PNS were reported in the bipolar group; reprogramming of the device was sufficient to prevent PNS in 3 patients, the fourth is pending solution. One PNS successfully managed noninvasively occurred in the quadripolar group. By Kaplan-Meier analysis, event-free survival for the combined primary outcome was significantly lower in patients with quadripolar leads (P = .037). Conclusion This prospective, controlled study provides strong evidence that CRT with the quadripolar LV lead results in low rates of dislocations and phrenic nerve stimulation.

AB - Background Flexible left ventricular (LV) pacing configurations are a useful component of cardiac resynchronization therapy (CRT) systems for preventing high LV pacing thresholds and phrenic nerve stimulation (PNS). A quadripolar LV lead has recently been designed with the purpose of allowing more choices in lead placement location and programming capability. Objective To verify the effectiveness of quadripolar LV leads compared to conventional bipolar LV leads implant outcomes. Methods Forty-five consecutive patients underwent implantation with either the quadripolar (n = 22; quadripolar group) or a conventional bipolar LV lead (n = 23; bipolar group). The primary outcome of the study was LV lead failure, defined as the need for lead revision or reprogramming during the first 3 months after implantation. Additionally, operative and follow-up data were prospectively noted and checked for significance between groups. Results The implantation success rate in both groups was 100%. Baseline characteristics, procedure duration, and fluoroscopy time did not differ significantly between groups. Two lead dislodgments (requiring reoperation) and 4 clinical PNS were reported in the bipolar group; reprogramming of the device was sufficient to prevent PNS in 3 patients, the fourth is pending solution. One PNS successfully managed noninvasively occurred in the quadripolar group. By Kaplan-Meier analysis, event-free survival for the combined primary outcome was significantly lower in patients with quadripolar leads (P = .037). Conclusion This prospective, controlled study provides strong evidence that CRT with the quadripolar LV lead results in low rates of dislocations and phrenic nerve stimulation.

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