Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis: Results from the italian prospective multicenter trial

Augusto D'Onofrio, Alessandro Mazzucco, Carlo Valfrè, Claudio Zussa, Luigi Martinelli, Riccardo Casabona, Alessandro Mazzola, Tiziano Gherli, Luigi P. Badano, Alessandro Fabbri

Research output: Contribution to journalArticle

Abstract

Background and aim of the study: The aims of this multicenter prospective observational trial were to evaluate: (i) the left ventricular remodeling, hemodynamics and early clinical outcomes of patients undergoing aortic valve replacement (AVR) with the Pericarbon Freedom (PF) stentless bioprosthesis; and (ii) the impact of the two suture techniques - continuous and interrupted - on the hemodynamic performance of the bioprosthesis. Methods: Between November 2001 and April 2004, a total of 226 patients (131 females, 95 males; mean age 73.2 ± 8.8 years) underwent AVR with the PF valve (Sorin Group, Saluggia, Italy) at eight Italian cardiac surgery centers. Associated surgery was performed in 73 patients (32%); of these operations, 54 were coronary artery bypass grafting . A continuous-suture technique was used in 132 patients (58%), and an interrupted-suture in 90 (40%). The suture technique was not available for four patients. All patients underwent clinical and echocardiographic evaluation immediately before surgery, and at one, six, and 12 months thereafter. The median follow up was 380 days (Q1: 363 days; Q3: 410 days), and the total cumulative follow up 236.9 patient-years (pt-yr). Results: The overall 30-day mortality was 3.5% (n = 8). Late deaths occurred in 10 patients (4%/pt-yr), of which three were valve-related (1%/pt-yr). The overall and valve-related survivals at one year were 92 ± 2% and 98 ± 1%, respectively. Freedom from structural valve deterioration, endocarditis, reoperation and thromboembolic events was 100%, 93 ± 1%, 98 ± 1% and 99 ± 1% at one year, respectively. The peak and mean transprosthetic gradients at one year were: 19.7 ± 12.27 and 8.7 ± 6.0 mmHg, respectively. After 12 months, significant reductions (compared to preoperative) were observed in the left ventricular mass (148.5 ± 48.8 versus 194.4 ± 54.6 g/m2; p

Original languageEnglish
Pages (from-to)531-539
Number of pages9
JournalJournal of Heart Valve Disease
Volume20
Issue number5
Publication statusPublished - Sep 2011

Fingerprint

Bioprosthesis
Ventricular Remodeling
Aortic Valve
Multicenter Studies
Hemodynamics
Suture Techniques
Endocarditis
Reoperation
Coronary Artery Bypass
Sutures
Italy
Thoracic Surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis : Results from the italian prospective multicenter trial. / D'Onofrio, Augusto; Mazzucco, Alessandro; Valfrè, Carlo; Zussa, Claudio; Martinelli, Luigi; Casabona, Riccardo; Mazzola, Alessandro; Gherli, Tiziano; Badano, Luigi P.; Fabbri, Alessandro.

In: Journal of Heart Valve Disease, Vol. 20, No. 5, 09.2011, p. 531-539.

Research output: Contribution to journalArticle

D'Onofrio, A, Mazzucco, A, Valfrè, C, Zussa, C, Martinelli, L, Casabona, R, Mazzola, A, Gherli, T, Badano, LP & Fabbri, A 2011, 'Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis: Results from the italian prospective multicenter trial', Journal of Heart Valve Disease, vol. 20, no. 5, pp. 531-539.
D'Onofrio, Augusto ; Mazzucco, Alessandro ; Valfrè, Carlo ; Zussa, Claudio ; Martinelli, Luigi ; Casabona, Riccardo ; Mazzola, Alessandro ; Gherli, Tiziano ; Badano, Luigi P. ; Fabbri, Alessandro. / Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis : Results from the italian prospective multicenter trial. In: Journal of Heart Valve Disease. 2011 ; Vol. 20, No. 5. pp. 531-539.
@article{cc55ab38ee9442ff9fc5459ea55f69f5,
title = "Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis: Results from the italian prospective multicenter trial",
abstract = "Background and aim of the study: The aims of this multicenter prospective observational trial were to evaluate: (i) the left ventricular remodeling, hemodynamics and early clinical outcomes of patients undergoing aortic valve replacement (AVR) with the Pericarbon Freedom (PF) stentless bioprosthesis; and (ii) the impact of the two suture techniques - continuous and interrupted - on the hemodynamic performance of the bioprosthesis. Methods: Between November 2001 and April 2004, a total of 226 patients (131 females, 95 males; mean age 73.2 ± 8.8 years) underwent AVR with the PF valve (Sorin Group, Saluggia, Italy) at eight Italian cardiac surgery centers. Associated surgery was performed in 73 patients (32{\%}); of these operations, 54 were coronary artery bypass grafting . A continuous-suture technique was used in 132 patients (58{\%}), and an interrupted-suture in 90 (40{\%}). The suture technique was not available for four patients. All patients underwent clinical and echocardiographic evaluation immediately before surgery, and at one, six, and 12 months thereafter. The median follow up was 380 days (Q1: 363 days; Q3: 410 days), and the total cumulative follow up 236.9 patient-years (pt-yr). Results: The overall 30-day mortality was 3.5{\%} (n = 8). Late deaths occurred in 10 patients (4{\%}/pt-yr), of which three were valve-related (1{\%}/pt-yr). The overall and valve-related survivals at one year were 92 ± 2{\%} and 98 ± 1{\%}, respectively. Freedom from structural valve deterioration, endocarditis, reoperation and thromboembolic events was 100{\%}, 93 ± 1{\%}, 98 ± 1{\%} and 99 ± 1{\%} at one year, respectively. The peak and mean transprosthetic gradients at one year were: 19.7 ± 12.27 and 8.7 ± 6.0 mmHg, respectively. After 12 months, significant reductions (compared to preoperative) were observed in the left ventricular mass (148.5 ± 48.8 versus 194.4 ± 54.6 g/m2; p",
author = "Augusto D'Onofrio and Alessandro Mazzucco and Carlo Valfr{\`e} and Claudio Zussa and Luigi Martinelli and Riccardo Casabona and Alessandro Mazzola and Tiziano Gherli and Badano, {Luigi P.} and Alessandro Fabbri",
year = "2011",
month = "9",
language = "English",
volume = "20",
pages = "531--539",
journal = "Journal of Heart Valve Disease",
issn = "0966-8519",
publisher = "ICR Publishers Ltd",
number = "5",

}

TY - JOUR

T1 - Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the pericarbon freedom stentless bioprosthesis

T2 - Results from the italian prospective multicenter trial

AU - D'Onofrio, Augusto

AU - Mazzucco, Alessandro

AU - Valfrè, Carlo

AU - Zussa, Claudio

AU - Martinelli, Luigi

AU - Casabona, Riccardo

AU - Mazzola, Alessandro

AU - Gherli, Tiziano

AU - Badano, Luigi P.

AU - Fabbri, Alessandro

PY - 2011/9

Y1 - 2011/9

N2 - Background and aim of the study: The aims of this multicenter prospective observational trial were to evaluate: (i) the left ventricular remodeling, hemodynamics and early clinical outcomes of patients undergoing aortic valve replacement (AVR) with the Pericarbon Freedom (PF) stentless bioprosthesis; and (ii) the impact of the two suture techniques - continuous and interrupted - on the hemodynamic performance of the bioprosthesis. Methods: Between November 2001 and April 2004, a total of 226 patients (131 females, 95 males; mean age 73.2 ± 8.8 years) underwent AVR with the PF valve (Sorin Group, Saluggia, Italy) at eight Italian cardiac surgery centers. Associated surgery was performed in 73 patients (32%); of these operations, 54 were coronary artery bypass grafting . A continuous-suture technique was used in 132 patients (58%), and an interrupted-suture in 90 (40%). The suture technique was not available for four patients. All patients underwent clinical and echocardiographic evaluation immediately before surgery, and at one, six, and 12 months thereafter. The median follow up was 380 days (Q1: 363 days; Q3: 410 days), and the total cumulative follow up 236.9 patient-years (pt-yr). Results: The overall 30-day mortality was 3.5% (n = 8). Late deaths occurred in 10 patients (4%/pt-yr), of which three were valve-related (1%/pt-yr). The overall and valve-related survivals at one year were 92 ± 2% and 98 ± 1%, respectively. Freedom from structural valve deterioration, endocarditis, reoperation and thromboembolic events was 100%, 93 ± 1%, 98 ± 1% and 99 ± 1% at one year, respectively. The peak and mean transprosthetic gradients at one year were: 19.7 ± 12.27 and 8.7 ± 6.0 mmHg, respectively. After 12 months, significant reductions (compared to preoperative) were observed in the left ventricular mass (148.5 ± 48.8 versus 194.4 ± 54.6 g/m2; p

AB - Background and aim of the study: The aims of this multicenter prospective observational trial were to evaluate: (i) the left ventricular remodeling, hemodynamics and early clinical outcomes of patients undergoing aortic valve replacement (AVR) with the Pericarbon Freedom (PF) stentless bioprosthesis; and (ii) the impact of the two suture techniques - continuous and interrupted - on the hemodynamic performance of the bioprosthesis. Methods: Between November 2001 and April 2004, a total of 226 patients (131 females, 95 males; mean age 73.2 ± 8.8 years) underwent AVR with the PF valve (Sorin Group, Saluggia, Italy) at eight Italian cardiac surgery centers. Associated surgery was performed in 73 patients (32%); of these operations, 54 were coronary artery bypass grafting . A continuous-suture technique was used in 132 patients (58%), and an interrupted-suture in 90 (40%). The suture technique was not available for four patients. All patients underwent clinical and echocardiographic evaluation immediately before surgery, and at one, six, and 12 months thereafter. The median follow up was 380 days (Q1: 363 days; Q3: 410 days), and the total cumulative follow up 236.9 patient-years (pt-yr). Results: The overall 30-day mortality was 3.5% (n = 8). Late deaths occurred in 10 patients (4%/pt-yr), of which three were valve-related (1%/pt-yr). The overall and valve-related survivals at one year were 92 ± 2% and 98 ± 1%, respectively. Freedom from structural valve deterioration, endocarditis, reoperation and thromboembolic events was 100%, 93 ± 1%, 98 ± 1% and 99 ± 1% at one year, respectively. The peak and mean transprosthetic gradients at one year were: 19.7 ± 12.27 and 8.7 ± 6.0 mmHg, respectively. After 12 months, significant reductions (compared to preoperative) were observed in the left ventricular mass (148.5 ± 48.8 versus 194.4 ± 54.6 g/m2; p

UR - http://www.scopus.com/inward/record.url?scp=84855364879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855364879&partnerID=8YFLogxK

M3 - Article

C2 - 22066357

AN - SCOPUS:84855364879

VL - 20

SP - 531

EP - 539

JO - Journal of Heart Valve Disease

JF - Journal of Heart Valve Disease

SN - 0966-8519

IS - 5

ER -