Left ventricular response to β-adrenergic stimulation in aging rats

Serge Masson, Beatrice Arosio, Fabio Fiordaliso, Nicoletta Gagliano, Laura Calvillo, Daniela Santambrogio, Silvia D'Aquila, Carlo Vergani, Roberto Latini, Giorgio Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of heart failure in the population increases steeply among older people. Overactivation of the sympathetic nervous system is associated to and responsible for worsening of heart failure. This study describes the influence of aging on short-term left ventricular (LV) adaptation to b- adrenergic stimulation in Wistar rats. In controls at 18 mo, interstitial fibrosis was increased with respect to 3-mo-old rats, whereas myocytes dimension and the messenger RNA (mRNA) abundance of atrial natriuretic peptide (ANP), a2(I) procollagen, transforming growth factor (TGF-b1, TGF- b3), and secreted protein, acidic and rich in cysteine (SPARC) were not different. To determine how aging affects LV adaptation to adrenergic stimulation, two groups of animals received isoproterenol (ISO, 1 mg/kg/d) for 3 days. There was no significant difference between young and older rats with respect to increase in LV weight, myocytes dimension, and mRNA abundance of all the genes considered, except a1(III) procollagen. These findings indicate that despite limited compensatory hypertrophy and higher fibrosis, LV from aged nonsenescent rats preserves the capacity to adapt to b- adrenergic stimulation through the upregulation of several genes encoding extracellular matrix-related proteins.

Original languageEnglish
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume55
Issue number1
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Ageing

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