TY - JOUR
T1 - Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT)
T2 - Rationale and design
AU - Ghio, Stefano
AU - Bonderman, Diana
AU - Felix, Stephan B.
AU - Ghofrani, Hossein A.
AU - Michelakis, Evangelos D.
AU - Mitrovic, Veselin
AU - Oudiz, Ronald J.
AU - Frey, Reiner
AU - Roessig, Lothar
AU - Semigran, Marc J.
PY - 2012/8
Y1 - 2012/8
N2 - Aims Pulmonary hypertension (PH) due to systolic left ventricular dysfunction (PH-sLVD) frequently complicates heart failure (HF), and greatly worsens the prognosis of patients with sLVD, but as yet has no approved treatment. The LEPHT study Aims to characterize the haemodynamic profile, safety, tolerability, and pharmacokinetic profile of riociguat (BAY 63-2521), an oral stimulator of soluble guanylate cyclase, in patients with PH-sLVD.Methods and resultsThis 16-week, phase IIb, randomized, placebo-controlled, double-blind study enrols patients with PH-sLVD, defined as left ventricular ejection fraction (LVEF) ≤40 and mean pulmonary arterial pressure (PAPmean)
AB - Aims Pulmonary hypertension (PH) due to systolic left ventricular dysfunction (PH-sLVD) frequently complicates heart failure (HF), and greatly worsens the prognosis of patients with sLVD, but as yet has no approved treatment. The LEPHT study Aims to characterize the haemodynamic profile, safety, tolerability, and pharmacokinetic profile of riociguat (BAY 63-2521), an oral stimulator of soluble guanylate cyclase, in patients with PH-sLVD.Methods and resultsThis 16-week, phase IIb, randomized, placebo-controlled, double-blind study enrols patients with PH-sLVD, defined as left ventricular ejection fraction (LVEF) ≤40 and mean pulmonary arterial pressure (PAPmean)
KW - Clinical trial
KW - Pulmonary hypertension
KW - Riociguat
KW - Soluble guanylate cyclase stimulator
KW - Systolic heart failure
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U2 - 10.1093/eurjhf/hfs071
DO - 10.1093/eurjhf/hfs071
M3 - Article
C2 - 22719060
AN - SCOPUS:84864452791
VL - 14
SP - 946
EP - 953
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 8
ER -