Ulcere delle gambe e melanonichia in bande longitudinali e trasversali in corso di terapia con idrossiurea

Translated title of the contribution: Leg ulcers, longitudinal and transverse melanonychia following hydroxyurea therapy

A. Bonci, V. Di Lernia, G. Bisighini

Research output: Contribution to journalArticlepeer-review


The authors report a 79 year-old-woman with essential thrombocytosis treated with hydroxyurea (1.000-1.500 mg/day) since 3 years, who developed after 2 years multiple painful ulcers on both lower legs. In addition nail, and toenail melanonychia striata was noted. The ulcers were located on the malleoli, ankles, and heels. More recently, transverse melanonychia in a few nails was observed. There was no diabetes mellitus or underlying vascular disease. The treatment consisted in local dressing and rest with slow improvement of the ulcers. Hydroxyurea is a cytostatic agent used mainly in patients with myeloproliferative disorders. Several cutaneous side effects have been described during long-term hydroxyurea treatment, such as xerosis and atrophy, ulcers, diffuse hyperpigmentation, chromonychia, dermatomyositis-like-eruptions, basal and squamous cell carcinomas. Cutaneous side-effects induced by hydroxyurea are underestimated because they are usually benign. If hydroxyurea is required for internal disease, as well as in our case, therapy could be continued. However, refractory painful leg ulcers and squamous cell carcinomas are the conditions which need to change the treatment. Melanonychia striata is the usual pattern of nail hyperpigmentation although diffuse and transverse hyperpigmentation can be rarely observed.

Translated title of the contributionLeg ulcers, longitudinal and transverse melanonychia following hydroxyurea therapy
Original languageItalian
Pages (from-to)231-235
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Leg ulcers, longitudinal and transverse melanonychia following hydroxyurea therapy'. Together they form a unique fingerprint.

Cite this