Leiomyomatosis peritonealis disseminata in association with Currarino syndrome?

Carmine Nappi, Attillio Di Spiezio Sardo, Vincenzo Dario Mandato, Giuseppe Bifulco, Elisa Merello, Antonio Savanelli, Chiara Mignogna, Valeria Capra, Maurizio Guida

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Leiomyomatosis peritonealis disseminata (LPD) is a rare disease in which multiple smooth muscle or smooth muscle-like nodules develop subperitoneally in any part of the abdominal cavity. No reports of multiple congenital malformations associated with LPD have been found in the English literature. Case presentation: A 27 year-old patient referred to our gynaecology unit for pelvic pain, amenorrhoea, stress incontinence, chronic constipation and recurrent intestinal and urinary infections. Multiple congenital malformations had previously been diagnosed. Most of these had required surgical treatment in her early life: anorectal malformation with rectovestibular fistula, ectopic right ureteral orifice, megadolichoureter and hemisacrum. An ultrasound scan and computed tomography performed in our department showed an irregular, polylobate, complex 20 cm mass originating from the right pelvis that reached the right hypochondrium and the epigastrium. The patient underwent laparotomy. The three largest abdominal-pelvic masses and multiple independent nodules within the peritoneum were progressively removed. The histological diagnosis was of LPD. Conclusion: The case we report is distinctive in that a rare acquired disease, LPD, coexists with multiple congenital malformations recalling a particular subgroup of caudal regression syndrome: the Currarino syndrome.

Original languageEnglish
Article number127
JournalBMC Cancer
Volume6
DOIs
Publication statusPublished - May 10 2006

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Leiomyomatosis
Rare Diseases
Smooth Muscle
Literature
Pelvic Pain
Abdominal Cavity
Peritoneum
Amenorrhea
Constipation
Pelvis
Gynecology
Laparotomy
Fistula
Tomography
Currarino triad
Infection

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nappi, C., Di Spiezio Sardo, A., Mandato, V. D., Bifulco, G., Merello, E., Savanelli, A., ... Guida, M. (2006). Leiomyomatosis peritonealis disseminata in association with Currarino syndrome? BMC Cancer, 6, [127]. https://doi.org/10.1186/1471-2407-6-127

Leiomyomatosis peritonealis disseminata in association with Currarino syndrome? / Nappi, Carmine; Di Spiezio Sardo, Attillio; Mandato, Vincenzo Dario; Bifulco, Giuseppe; Merello, Elisa; Savanelli, Antonio; Mignogna, Chiara; Capra, Valeria; Guida, Maurizio.

In: BMC Cancer, Vol. 6, 127, 10.05.2006.

Research output: Contribution to journalArticle

Nappi, C, Di Spiezio Sardo, A, Mandato, VD, Bifulco, G, Merello, E, Savanelli, A, Mignogna, C, Capra, V & Guida, M 2006, 'Leiomyomatosis peritonealis disseminata in association with Currarino syndrome?', BMC Cancer, vol. 6, 127. https://doi.org/10.1186/1471-2407-6-127
Nappi, Carmine ; Di Spiezio Sardo, Attillio ; Mandato, Vincenzo Dario ; Bifulco, Giuseppe ; Merello, Elisa ; Savanelli, Antonio ; Mignogna, Chiara ; Capra, Valeria ; Guida, Maurizio. / Leiomyomatosis peritonealis disseminata in association with Currarino syndrome?. In: BMC Cancer. 2006 ; Vol. 6.
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