Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients

Nicola Gianotti, Myriam Maillard, Giovanni Gaiera, Arabella Bestetti, Massimo Cernuschi, Anna De Bona, Adriano Lazzarin, Paola Cinque, Simona Bossolasco

Research output: Contribution to journalArticle

Abstract

An HIV-infected patient started combination antiretroviral therapy with 13 CD4+ cells/μL. Despite sustained virological suppression over the following four years, the anemia did not resolve, and the CD4+ cell counts always remained below 200/pL until co-infection with Leishmania was diagnosed in October 2006 when the patient started complaining of persistent mild fever and asthenia. Once treatment for leishmaniasis was started with miltefosine, CD4+ cell count rose above 400/μL A new drop in CD4+ cell count was observed when Leishmania DNA turned out again to be positive, but treatment with liposomal amphotericin-B restored immune recovery.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalNew Microbiologica
Volume31
Issue number3
Publication statusPublished - Jul 2008

Keywords

  • HAART
  • HIV-1
  • Immune reconstitution
  • Leishmaniasis

ASJC Scopus subject areas

  • Microbiology (medical)

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    Gianotti, N., Maillard, M., Gaiera, G., Bestetti, A., Cernuschi, M., De Bona, A., Lazzarin, A., Cinque, P., & Bossolasco, S. (2008). Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients. New Microbiologica, 31(3), 435-438.