Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma

Lotfi Benboubker; Meletios A. Dimopoulos; Angela Dispenzieri; John Catalano; Andrew R. Belch; Michele Cavo; Antonello Pinto; Katja Weisel; Heinz Ludwig; Nizar Bahlis; Anne Banos; Mourad Tiab; Michel Delforge; Jamie Cavenagh; Catarina Geraldes; Je Jung Lee; Christine Chen; Albert Oriol; Javier De La Rubia; Lugui Qiu; Darrell J. White; Daniel Binder; Kenneth Anderson; Jean Paul Fermand; Philippe Moreau; Michel Attal; Robert Knight; Guang Chen; Jason Van Oostendorp; Christian Jacques; Annette Ervin-Haynes; Hervé Avet-Loiseau; Cyrille Hulin; Thierry Facon

doi:10.1056/NEJMoa1402551

Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma

Lotfi Benboubker, Meletios A. Dimopoulos, Angela Dispenzieri, John Catalano, Andrew R. Belch, Michele Cavo, Antonello Pinto, Katja Weisel, Heinz Ludwig, Nizar Bahlis, Anne Banos, Mourad Tiab, Michel Delforge, Jamie Cavenagh, Catarina Geraldes, Je Jung Lee, Christine Chen, Albert Oriol, Javier De La Rubia, Lugui QiuDarrell J. White, Daniel Binder, Kenneth Anderson, Jean Paul Fermand, Philippe Moreau, Michel Attal, Robert Knight, Guang Chen, Jason Van Oostendorp, Christian Jacques, Annette Ervin-Haynes, Hervé Avet-Loiseau, Cyrille Hulin, Thierry Facon

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. Methods: We randomly assigned 1623 patients to lenalidomide and dexamethasone in 28-day cycles until disease progression (535 patients), to the same combination for 72 weeks (18 cycles; 541 patients), or to MPT for 72 weeks (547 patients). The primary end point was progression-free survival with continuous lenalidomide-dexamethasone versus MPT. Results: The median progression-free survival was 25.5 months with continuous lenalidomide-dexamethasone, 20.7 months with 18 cycles of lenalidomide-dexamethasone, and 21.2 months with MPT (hazard ratio for the risk of progression or death, 0.72 for continuous lenalidomide-dexamethasone vs. MPT and 0.70 for continuous lenalidomide-dexamethasone vs. 18 cycles of lenalidomide-dexamethasone; P

Original language	English
Pages (from-to)	906-917
Number of pages	12
Journal	New England Journal of Medicine
Volume	371
Issue number	10
DOIs	https://doi.org/10.1056/NEJMoa1402551
Publication status	Published - Sep 4 2014

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Medicine(all)

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10.1056/NEJMoa1402551

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Benboubker, L., Dimopoulos, M. A., Dispenzieri, A., Catalano, J., Belch, A. R., Cavo, M., Pinto, A., Weisel, K., Ludwig, H., Bahlis, N., Banos, A., Tiab, M., Delforge, M., Cavenagh, J., Geraldes, C., Lee, J. J., Chen, C., Oriol, A., De La Rubia, J., ... Facon, T. (2014). Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. New England Journal of Medicine, 371(10), 906-917. https://doi.org/10.1056/NEJMoa1402551

Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. / Benboubker, Lotfi; Dimopoulos, Meletios A.; Dispenzieri, Angela; Catalano, John; Belch, Andrew R.; Cavo, Michele; Pinto, Antonello; Weisel, Katja; Ludwig, Heinz; Bahlis, Nizar; Banos, Anne; Tiab, Mourad; Delforge, Michel; Cavenagh, Jamie; Geraldes, Catarina; Lee, Je Jung; Chen, Christine; Oriol, Albert; De La Rubia, Javier; Qiu, Lugui; White, Darrell J.; Binder, Daniel; Anderson, Kenneth; Fermand, Jean Paul; Moreau, Philippe; Attal, Michel; Knight, Robert; Chen, Guang; Van Oostendorp, Jason; Jacques, Christian; Ervin-Haynes, Annette; Avet-Loiseau, Hervé; Hulin, Cyrille; Facon, Thierry.

In: New England Journal of Medicine, Vol. 371, No. 10, 04.09.2014, p. 906-917.

Research output: Contribution to journal › Article › peer-review

Benboubker, L, Dimopoulos, MA, Dispenzieri, A, Catalano, J, Belch, AR, Cavo, M, Pinto, A, Weisel, K, Ludwig, H, Bahlis, N, Banos, A, Tiab, M, Delforge, M, Cavenagh, J, Geraldes, C, Lee, JJ, Chen, C, Oriol, A, De La Rubia, J, Qiu, L, White, DJ, Binder, D, Anderson, K, Fermand, JP, Moreau, P, Attal, M, Knight, R, Chen, G, Van Oostendorp, J, Jacques, C, Ervin-Haynes, A, Avet-Loiseau, H, Hulin, C & Facon, T 2014, 'Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma', New England Journal of Medicine, vol. 371, no. 10, pp. 906-917. https://doi.org/10.1056/NEJMoa1402551

Benboubker, Lotfi ; Dimopoulos, Meletios A. ; Dispenzieri, Angela ; Catalano, John ; Belch, Andrew R. ; Cavo, Michele ; Pinto, Antonello ; Weisel, Katja ; Ludwig, Heinz ; Bahlis, Nizar ; Banos, Anne ; Tiab, Mourad ; Delforge, Michel ; Cavenagh, Jamie ; Geraldes, Catarina ; Lee, Je Jung ; Chen, Christine ; Oriol, Albert ; De La Rubia, Javier ; Qiu, Lugui ; White, Darrell J. ; Binder, Daniel ; Anderson, Kenneth ; Fermand, Jean Paul ; Moreau, Philippe ; Attal, Michel ; Knight, Robert ; Chen, Guang ; Van Oostendorp, Jason ; Jacques, Christian ; Ervin-Haynes, Annette ; Avet-Loiseau, Hervé ; Hulin, Cyrille ; Facon, Thierry. / Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. In: New England Journal of Medicine. 2014 ; Vol. 371, No. 10. pp. 906-917.

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abstract = "Background: The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. Methods: We randomly assigned 1623 patients to lenalidomide and dexamethasone in 28-day cycles until disease progression (535 patients), to the same combination for 72 weeks (18 cycles; 541 patients), or to MPT for 72 weeks (547 patients). The primary end point was progression-free survival with continuous lenalidomide-dexamethasone versus MPT. Results: The median progression-free survival was 25.5 months with continuous lenalidomide-dexamethasone, 20.7 months with 18 cycles of lenalidomide-dexamethasone, and 21.2 months with MPT (hazard ratio for the risk of progression or death, 0.72 for continuous lenalidomide-dexamethasone vs. MPT and 0.70 for continuous lenalidomide-dexamethasone vs. 18 cycles of lenalidomide-dexamethasone; P",

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AU - Dimopoulos, Meletios A.

AU - Dispenzieri, Angela

AU - Catalano, John

AU - Belch, Andrew R.

AU - Cavo, Michele

AU - Pinto, Antonello

AU - Weisel, Katja

AU - Ludwig, Heinz

AU - Bahlis, Nizar

AU - Banos, Anne

AU - Tiab, Mourad

AU - Delforge, Michel

AU - Cavenagh, Jamie

AU - Geraldes, Catarina

AU - Lee, Je Jung

AU - Chen, Christine

AU - Oriol, Albert

AU - De La Rubia, Javier

AU - Qiu, Lugui

AU - White, Darrell J.

AU - Binder, Daniel

AU - Anderson, Kenneth

AU - Fermand, Jean Paul

AU - Moreau, Philippe

AU - Attal, Michel

AU - Knight, Robert

AU - Chen, Guang

AU - Van Oostendorp, Jason

AU - Jacques, Christian

AU - Ervin-Haynes, Annette

AU - Avet-Loiseau, Hervé

AU - Hulin, Cyrille

AU - Facon, Thierry

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Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma

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