Lentiviral effector pathways of TRIM proteins

Filippo Turrini, Andrea Di Pietro, Elisa Vicenzi

Research output: Contribution to journalArticlepeer-review


The human tripartite motif (TRIM) family, composed of more than 77 members, encompasses an emerging group of innate antiviral factors. Most TRIM proteins are characterized by being E3 ubiquitin ligases, but also engage in specific interactions with a variety of cellular and viral partners. They are involved in many cellular processes, including cell differentiation, transcriptional regulation, cytoskeleton remodeling, intracellular trafficking, membrane repair, and oncogenesis. In regard to antiviral immunity, they restrict both retroviruses and lentiviruses as well as other DNA and RNA viruses. This review will focus on the TRIM members endowed with anti-retroviral and anti-lentiviral activities and, in particular, human immunodeficiency virus.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalDNA and Cell Biology
Issue number4
Publication statusPublished - Apr 1 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology


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