Lentiviral vectors: Excellent tools for experimental gene transfer and promising candidates for gene therapy

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Abstract

Lentiviral vectors are tools for gene transfer derived from lentiviruses. From their first application to now they have been strongly developed in design, in biosafety and in their ability of transgene expression into target cells. Primate and non-primate derived lentiviral vectors are now available and with both types of systems a lot of studies tuned to improve their performances in a large number of tissues are ongoing. Here we review the state of the art of lentiviral vector systems discussing their potential for gene therapy.

Original languageEnglish
Pages (from-to)308-316
Number of pages9
JournalJournal of Gene Medicine
Volume2
Issue number5
Publication statusPublished - Sep 2000

Keywords

  • Biosafety
  • Gene therapy
  • Gene transfer
  • HIV-derived vector
  • Lentiviral vector
  • Non-primate lentiviral vectors

ASJC Scopus subject areas

  • Genetics

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