Lentiviruses as gene transfer agents for delivery to non-dividing cells

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Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences non-essential for transduction. Other vectors have also been developed from non-primate lentiviruses.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalCurrent Opinion in Biotechnology
Issue number5
Publication statusPublished - Oct 1998

ASJC Scopus subject areas

  • Biotechnology


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