Lentiviruses as gene transfer agents for delivery to non-dividing cells

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences non-essential for transduction. Other vectors have also been developed from non-primate lentiviruses.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume9
Issue number5
DOIs
Publication statusPublished - Oct 1998

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Gene transfer
Lentivirus
Transgenes
Retina
HIV
Muscles
Liver
Brain
Genes
Muscle
Tissue

ASJC Scopus subject areas

  • Biotechnology

Cite this

Lentiviruses as gene transfer agents for delivery to non-dividing cells. / Naldini, Luigi.

In: Current Opinion in Biotechnology, Vol. 9, No. 5, 10.1998, p. 457-463.

Research output: Contribution to journalArticle

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