Leptin: adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery

Giuseppe Danilo Norata, Sara Raselli, Liliana Grigore, Katia Garlaschelli, Elena Dozio, Paolo Magni, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND PURPOSE - The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. METHODS - We investigated, therefore, the relationship between L:A ratio and intima media thickness (IMT), an independent predictor of cardiovascular disease, in 110 healthy males. RESULTS - L:A ratio was significantly correlated to body mass index, waist, hip, waist-to-hip ratio, systolic blood pressure, IMT, high-density lipoprotein, apolipoprotein A-I, glucose, and the homeostasis model of insulin resistance-revised. No significant correlation was observed with age, diastolic blood pressure, low-density lipoprotein, triglycerides, apolipoprotein B, ApoB/ApoA-I ratio, insulin, alanine transaminase, γ-glutamyl-transferase, and resistin. In addition, when the relationship between IMT and adiponectin or leptin alone was analyzed, only leptin plasma levels significantly associated with IMT (r=0.301, P30 kg/m) showed a significantly higher L:A ratio compared with nonobese subjects (1.20 versus 0.42, respectively, P

Original languageEnglish
Pages (from-to)2844-2846
Number of pages3
Issue number10
Publication statusPublished - Oct 2007


  • Body mass index
  • IMT
  • Leptin:adiponectin ratio
  • Waist-to-hip ratio

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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