TY - JOUR
T1 - Leptin
T2 - adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery
AU - Norata, Giuseppe Danilo
AU - Raselli, Sara
AU - Grigore, Liliana
AU - Garlaschelli, Katia
AU - Dozio, Elena
AU - Magni, Paolo
AU - Catapano, Alberico L.
PY - 2007/10
Y1 - 2007/10
N2 - BACKGROUND AND PURPOSE - The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. METHODS - We investigated, therefore, the relationship between L:A ratio and intima media thickness (IMT), an independent predictor of cardiovascular disease, in 110 healthy males. RESULTS - L:A ratio was significantly correlated to body mass index, waist, hip, waist-to-hip ratio, systolic blood pressure, IMT, high-density lipoprotein, apolipoprotein A-I, glucose, and the homeostasis model of insulin resistance-revised. No significant correlation was observed with age, diastolic blood pressure, low-density lipoprotein, triglycerides, apolipoprotein B, ApoB/ApoA-I ratio, insulin, alanine transaminase, γ-glutamyl-transferase, and resistin. In addition, when the relationship between IMT and adiponectin or leptin alone was analyzed, only leptin plasma levels significantly associated with IMT (r=0.301, P30 kg/m) showed a significantly higher L:A ratio compared with nonobese subjects (1.20 versus 0.42, respectively, P
AB - BACKGROUND AND PURPOSE - The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. METHODS - We investigated, therefore, the relationship between L:A ratio and intima media thickness (IMT), an independent predictor of cardiovascular disease, in 110 healthy males. RESULTS - L:A ratio was significantly correlated to body mass index, waist, hip, waist-to-hip ratio, systolic blood pressure, IMT, high-density lipoprotein, apolipoprotein A-I, glucose, and the homeostasis model of insulin resistance-revised. No significant correlation was observed with age, diastolic blood pressure, low-density lipoprotein, triglycerides, apolipoprotein B, ApoB/ApoA-I ratio, insulin, alanine transaminase, γ-glutamyl-transferase, and resistin. In addition, when the relationship between IMT and adiponectin or leptin alone was analyzed, only leptin plasma levels significantly associated with IMT (r=0.301, P30 kg/m) showed a significantly higher L:A ratio compared with nonobese subjects (1.20 versus 0.42, respectively, P
KW - Body mass index
KW - IMT
KW - Leptin:adiponectin ratio
KW - Waist-to-hip ratio
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U2 - 10.1161/STROKEAHA.107.485540
DO - 10.1161/STROKEAHA.107.485540
M3 - Article
C2 - 17823381
AN - SCOPUS:34848832114
VL - 38
SP - 2844
EP - 2846
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 10
ER -