Leptin affects the inflammatory response after STEMI

Andrea Demarchi, Iolanda Mazzucchelli, Alberto Somaschini, Stefano Cornara, Veronica Dusi, Alessandro Mandurino Mirizzi, Marta Ruffinazzi, Gabriele Crimi, Marco Ferlini, Massimiliano Gnecchi, Luigi Oltrona Visconti, Stefano De Servi, Gaetano M. De Ferrari

Research output: Contribution to journalArticle

Abstract

Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting.

Original languageEnglish
JournalNutrition, Metabolism and Cardiovascular Diseases
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • Acute inflammation and ischaemia-reperfusion damage
  • Leptin
  • ST elevation myocardial infarction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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