TY - JOUR
T1 - Leptin affects the inflammatory response after STEMI
AU - Demarchi, Andrea
AU - Mazzucchelli, Iolanda
AU - Somaschini, Alberto
AU - Cornara, Stefano
AU - Dusi, Veronica
AU - Mirizzi, Alessandro Mandurino
AU - Ruffinazzi, Marta
AU - Crimi, Gabriele
AU - Ferlini, Marco
AU - Gnecchi, Massimiliano
AU - Visconti, Luigi Oltrona
AU - De Servi, Stefano
AU - De Ferrari, Gaetano M.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting.
AB - Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting.
KW - Acute inflammation and ischaemia-reperfusion damage
KW - Leptin
KW - ST elevation myocardial infarction
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U2 - 10.1016/j.numecd.2020.02.004
DO - 10.1016/j.numecd.2020.02.004
M3 - Article
AN - SCOPUS:85082778753
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
ER -