Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Paola de Candia; Giuseppe Matarese

doi:10.1016/j.neuropharm.2017.12.025

Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Paola de Candia, Giuseppe Matarese

IRCCS Multimedica

Research output: Contribution to journal › Article

Abstract

Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

Original language	English
Journal	Neuropharmacology
DOIs	https://doi.org/10.1016/j.neuropharm.2017.12.025
Publication status	Accepted/In press - Jan 1 2017

Keywords

Ghrelin
Leptin
Metabolism
Neurodegeneration
Neuroinflammation

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/j.neuropharm.2017.12.025

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de Candia, P., & Matarese, G. (Accepted/In press). Leptin and ghrelin: Sewing metabolism onto neurodegeneration. Neuropharmacology. https://doi.org/10.1016/j.neuropharm.2017.12.025

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