Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Paola de Candia; Giuseppe Matarese

doi:10.1016/j.neuropharm.2017.12.025

Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Paola de Candia, Giuseppe Matarese

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

Original language	English
Journal	Neuropharmacology
DOIs	https://doi.org/10.1016/j.neuropharm.2017.12.025
Publication status	Accepted/In press - Jan 1 2017

Keywords

Ghrelin
Leptin
Metabolism
Neurodegeneration
Neuroinflammation

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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N2 - Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

AB - Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

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KW - Metabolism

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KW - Neuroinflammation

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Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Abstract

Keywords

ASJC Scopus subject areas

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