Abstract
Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.
Original language | English |
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Journal | Neuropharmacology |
DOIs | |
Publication status | Accepted/In press - Jan 1 2017 |
Keywords
- Ghrelin
- Leptin
- Metabolism
- Neurodegeneration
- Neuroinflammation
ASJC Scopus subject areas
- Pharmacology
- Cellular and Molecular Neuroscience