Leptin and ghrelin: Sewing metabolism onto neurodegeneration

Paola de Candia, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

Original languageEnglish
JournalNeuropharmacology
DOIs
Publication statusAccepted/In press - Jan 1 2017

Keywords

  • Ghrelin
  • Leptin
  • Metabolism
  • Neurodegeneration
  • Neuroinflammation

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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