TY - JOUR
T1 - Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta
AU - Batocchi, Anna Paola
AU - Rotondi, Mario
AU - Caggiula, Marcella
AU - Frisullo, Giovanni
AU - Odoardi, Francesca
AU - Nociti, Viviana
AU - Carella, Carlo
AU - Tonali, Pietro Attilio
AU - Mirabella, Massimiliano
PY - 2003/6
Y1 - 2003/6
N2 - The role of leptin was investigated in relapsing-remitting multiple sclerosis (MS). Control and MS patients showed comparable baseline serum leptin levels. During the first year of IFNbeta-1a treatment, leptin significantly decreased since 2 months after starting therapy in 11 patients who had no relapses. A significant decrease in IL12/IL10 ratio was observed in this group of patients only after 1 year of treatment. An increase of leptin was observed before the first clinical exacerbation in 13 relapsing patients. Leptin may play a pathogenic role in MS and can be a useful marker of disease activity and response to therapy.
AB - The role of leptin was investigated in relapsing-remitting multiple sclerosis (MS). Control and MS patients showed comparable baseline serum leptin levels. During the first year of IFNbeta-1a treatment, leptin significantly decreased since 2 months after starting therapy in 11 patients who had no relapses. A significant decrease in IL12/IL10 ratio was observed in this group of patients only after 1 year of treatment. An increase of leptin was observed before the first clinical exacerbation in 13 relapsing patients. Leptin may play a pathogenic role in MS and can be a useful marker of disease activity and response to therapy.
KW - Cytokines
KW - Interferon beta
KW - Leptin
KW - Multiple sclerosis
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U2 - 10.1016/S0165-5728(03)00154-1
DO - 10.1016/S0165-5728(03)00154-1
M3 - Article
C2 - 12799033
AN - SCOPUS:0038797814
VL - 139
SP - 150
EP - 154
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -