Leptin as immune mediator: Interaction between neuroendocrine and immune system

Claudio Procaccini, Claudia La Rocca, Fortunata Carbone, Veronica De Rosa, Mario Galgani, Giuseppe Matarese

Research output: Contribution to journalArticlepeer-review


Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates.

Original languageEnglish
JournalDevelopmental and Comparative Immunology
Publication statusAccepted/In press - Nov 3 2015


  • Adaptive immunity
  • Innate immunity
  • Leptin
  • Non-mammalian vertebrates

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology


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