Leptin as immune mediator: Interaction between neuroendocrine and immune system

Claudio Procaccini, Claudia La Rocca, Fortunata Carbone, Veronica De Rosa, Mario Galgani, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates.

Original languageEnglish
Pages (from-to)120-129
Number of pages10
JournalDevelopmental and Comparative Immunology
Volume66
DOIs
Publication statusE-pub ahead of print - Jun 8 2016

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Neurosecretory Systems
Leptin
Immune System
Hormones
Cytokines
Thermogenesis
Hematopoiesis
Adaptive Immunity
Nutritional Status
Adipocytes
Innate Immunity
Autoimmune Diseases
Reproduction
Vertebrates
Mammals
Homeostasis
Obesity

Keywords

  • Journal Article

Cite this

Procaccini, C., La Rocca, C., Carbone, F., De Rosa, V., Galgani, M., & Matarese, G. (2016). Leptin as immune mediator: Interaction between neuroendocrine and immune system. Developmental and Comparative Immunology, 66, 120-129. https://doi.org/10.1016/j.dci.2016.06.006

Leptin as immune mediator : Interaction between neuroendocrine and immune system. / Procaccini, Claudio; La Rocca, Claudia; Carbone, Fortunata; De Rosa, Veronica; Galgani, Mario; Matarese, Giuseppe.

In: Developmental and Comparative Immunology, Vol. 66, 08.06.2016, p. 120-129.

Research output: Contribution to journalArticle

Procaccini, C, La Rocca, C, Carbone, F, De Rosa, V, Galgani, M & Matarese, G 2016, 'Leptin as immune mediator: Interaction between neuroendocrine and immune system', Developmental and Comparative Immunology, vol. 66, pp. 120-129. https://doi.org/10.1016/j.dci.2016.06.006
Procaccini, Claudio ; La Rocca, Claudia ; Carbone, Fortunata ; De Rosa, Veronica ; Galgani, Mario ; Matarese, Giuseppe. / Leptin as immune mediator : Interaction between neuroendocrine and immune system. In: Developmental and Comparative Immunology. 2016 ; Vol. 66. pp. 120-129.
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