Leptin-based immune intervention: Current status and future directions

Antonio La Cava; Giuseppe Matarese; Fanny M. Ebling; Bevra H. Hahn

Leptin-based immune intervention: Current status and future directions

Antonio La Cava, Giuseppe Matarese, Fanny M. Ebling, Bevra H. Hahn

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.

Original language	English
Pages (from-to)	1327-1332
Number of pages	6
Journal	Current Opinion in Investigational Drugs
Volume	4
Issue number	11
Publication status	Published - Nov 2003

Keywords

Autoimmunity
Cytokines
Hormones
Immunotherapy
Leptin
T-helper 1

ASJC Scopus subject areas

Pharmacology

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