Leptin-based immune intervention: Current status and future directions

Antonio La Cava, Giuseppe Matarese, Fanny M. Ebling, Bevra H. Hahn

Research output: Contribution to journalArticlepeer-review


Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.

Original languageEnglish
Pages (from-to)1327-1332
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Issue number11
Publication statusPublished - Nov 2003


  • Autoimmunity
  • Cytokines
  • Hormones
  • Immunotherapy
  • Leptin
  • T-helper 1

ASJC Scopus subject areas

  • Pharmacology


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