Abstract
Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1327-1332 |
| Number of pages | 6 |
| Journal | Current Opinion in Investigational Drugs |
| Volume | 4 |
| Issue number | 11 |
| Publication status | Published - Nov 2003 |
Keywords
- Autoimmunity
- Cytokines
- Hormones
- Immunotherapy
- Leptin
- T-helper 1
ASJC Scopus subject areas
- Pharmacology