Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: Class-I cytokines involved in the neuroendocrine regulation of the reproductive function

E. Dozio, M. Ruscica, E. Galliera, M. M. Corsi, P. Magni

Research output: Contribution to journalArticle

Abstract

Class-I cytokines represent a large group of molecules involved in different physiological processes including host defence, immune regulation, food intake, energy metabolism and, relevant for this review, reproduction. In this latter respect, here, we focus the attention on four of these molecules, specifically leptin, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6). These cytokines present similar three-dimensional fold structure, interact with related class-I receptors, which are expressed in the same regions (i.e., hypothalamus), and activate similar intracellular pathways. Leptin and CNTF share functional similarities, by acting at hypothalamic and pituitary levels, and their receptors are colocalized in the arcuate and paraventricular nuclei of the hypothalamus. For both these molecules, no effect on GnRH migration has been described. LIF has also been shown to affect gonadotropin secretion and here we present the novel observation that it is also able to stimulate GnRH secretion in vitro. Moreover, in the mouse, LIF is prenatally expressed in nasal regions where GnRH neurons originate and start their migration, and in vitro it stimulates intrinsic cell motility and directional migration. The role of the prototypical cytokine, IL-6, on the GnRH-LH axis is not fully clear and additional information seem necessary to better clarify this aspect. In conclusion, the data here discussed suggest that this family of cytokines appears to participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites.

Original languageEnglish
Pages (from-to)577-584
Number of pages8
JournalCurrent Protein and Peptide Science
Volume10
Issue number6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • CNTF
  • GN11 cells
  • GnRH neurons
  • GT1-7 cells
  • IL-6
  • Leptin
  • LIF
  • Reproduction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: Class-I cytokines involved in the neuroendocrine regulation of the reproductive function'. Together they form a unique fingerprint.

  • Cite this