Leptin in non-autoimmune inflammation

Chunlin Cai; Bevra H. Hahn; Giuseppe Matarese; Antonio La Cava

doi:10.2174/187152809789352168

Leptin in non-autoimmune inflammation

Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese, Antonio La Cava

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis.

Original language	English
Pages (from-to)	285-291
Number of pages	7
Journal	Inflammation and Allergy - Drug Targets
Volume	8
Issue number	4
DOIs	https://doi.org/10.2174/187152809789352168
Publication status	Published - 2009

Keywords

Inflammation
Leptin
Metabolism

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pharmacology

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