Leptin in non-autoimmune inflammation

Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese, Antonio La Cava

Research output: Contribution to journalArticlepeer-review

Abstract

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalInflammation and Allergy - Drug Targets
Volume8
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Inflammation
  • Leptin
  • Metabolism

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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