Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines

Graham M. Lord, Giuseppe Matarese, Jane K. Howard, Stephen R. Bloom, Robert I. Lechler

Research output: Contribution to journalArticle

Abstract

There is increasing evidence that leptin affects immune responses and that in the absence of leptin, immunity is suboptimal. Most data so far indicate that leptin increases proinflammatory immune responses by an effect on T cells and macrophages. Here we show that, under certain circumstances, leptin can inhibit T cell proliferative responses. Separation of the responding T cells into different subpopulations revealed an interesting heterogeneity of cellular behavior in that naïve and memory T cells were differentially affected by leptin. The anti-CD3-driven proliferation of memory T cells was inhibited by leptin, whereas that of naïve T cells was markedly enhanced. Despite the inhibition of proliferation of the memory T cells, their production of interferon-γ was substantially increased. These data show that leptin can inhibit certain immune responses in vitro. However, despite this inhibition of proliferation, the production of proinflammatory cytokines is significantly enhanced by leptin. The findings demonstrated here show further complexity in the actions of leptin on the immune system.

Original languageEnglish
Pages (from-to)330-338
Number of pages9
JournalJournal of Leukocyte Biology
Volume72
Issue number2
Publication statusPublished - Aug 1 2002

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Leptin
Blood Cells
Cytokines
T-Lymphocytes
Interferons
Immune System
Immunity
Macrophages

Keywords

  • Immunity
  • Immunoglobulin
  • Interferon-γ
  • ObRb
  • T cell receptor

ASJC Scopus subject areas

  • Cell Biology

Cite this

Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. / Lord, Graham M.; Matarese, Giuseppe; Howard, Jane K.; Bloom, Stephen R.; Lechler, Robert I.

In: Journal of Leukocyte Biology, Vol. 72, No. 2, 01.08.2002, p. 330-338.

Research output: Contribution to journalArticle

Lord, Graham M. ; Matarese, Giuseppe ; Howard, Jane K. ; Bloom, Stephen R. ; Lechler, Robert I. / Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. In: Journal of Leukocyte Biology. 2002 ; Vol. 72, No. 2. pp. 330-338.
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