Leptin level lowers in proportion to the amount of aerobic work after four weeks of training in obesity

A. Salvadori, P. Fanari, A. Brunani, P. Marzullo, F. Codecasa, I. Tovaglieri, M. Cornacchia, P. Palmulli, E. Longhini

Research output: Contribution to journalArticlepeer-review


Leptin values are higher in obesity. Physical exercise reduces fat mass (FM) and decreases leptin levels. Intensity of physical training seems to play a role in reducing circulating leptin. In 16 obese subjects (8 men and 8 women, age 38.6±3.9 years, BMI 35.9±1.8 kg/m2), leptin was sampled before and after 4 weeks of controlled training. Eight subjects (4 men and 4 women) performed an aerobic training schedule (Group A), the remainders an aerobic training program with a bout of work beyond the anaerobic threshold (AT) (Group B). Training determined a reduction in leptin levels in both groups, which was significant in Group A (12.2 vs. 27.8μg/l, p2=0.89). In obesity, a reduction is observed in leptin levels after short-term training, which is seemingly dissociated from concomitant decrease of FM. Aerobic training alone appears to be linked to a greater leptin reduction, which is well correlated with the amount of work performed.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalHormone and Metabolic Research
Issue number3
Publication statusPublished - 2015


  • anaerobic threshold
  • insulin resistance
  • leptin
  • obesity
  • physical training

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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