Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression

Graham M. Lord, Giuseppe Matarese, Jane K. Howard, Richard J. Baker, Stephen R. Bloom, Robert I. Lechler

Research output: Contribution to journalArticle

1661 Citations (Scopus)

Abstract

Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight. Circulating levels of this adipocyte-derived hormone are proportional to fat mass but maybe lowered rapidly by fasting or increased by inflammatory mediators. The impaired T-cell immunity of mice now known to be defective in leptin (ob/ob) or its receptor (db/db), has never been explained. Impaired cell-mediated immunity and reduced levels of leptin are both features of low body weight in humans. Indeed, malnutrition predisposes to death from infectious diseases. We report here that leptin has a specific effect on T- lymphocyte responses, differentially regulating the proliferation of naive and memory T cells. Leptin increased Th1 and suppressed Th2 cytokine production. Administration of leptin to mice reversed the immunosuppressive effects of acute starvation. Our findings suggest a new role for leptin in linking nutritional status to cognate cellular immune function, and provide a molecular mechanism to account for the immune dysfunction observed in starvation.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalNature
Volume394
Issue number6696
DOIs
Publication statusPublished - Aug 27 1998

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Starvation
Leptin
Immunosuppression
T-Lymphocytes
Body Weight
Immunosuppressive Agents
Nutritional Status
Adipocytes
Cellular Immunity
Malnutrition
Communicable Diseases
Organism Cloning
Immunity
Fasting
Fats
Hormones
Cytokines
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., & Lechler, R. I. (1998). Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. Nature, 394(6696), 897-901. https://doi.org/10.1038/29795

Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. / Lord, Graham M.; Matarese, Giuseppe; Howard, Jane K.; Baker, Richard J.; Bloom, Stephen R.; Lechler, Robert I.

In: Nature, Vol. 394, No. 6696, 27.08.1998, p. 897-901.

Research output: Contribution to journalArticle

Lord, GM, Matarese, G, Howard, JK, Baker, RJ, Bloom, SR & Lechler, RI 1998, 'Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression', Nature, vol. 394, no. 6696, pp. 897-901. https://doi.org/10.1038/29795
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. Nature. 1998 Aug 27;394(6696):897-901. https://doi.org/10.1038/29795
Lord, Graham M. ; Matarese, Giuseppe ; Howard, Jane K. ; Baker, Richard J. ; Bloom, Stephen R. ; Lechler, Robert I. / Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression. In: Nature. 1998 ; Vol. 394, No. 6696. pp. 897-901.
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