TY - JOUR
T1 - Leptin signaling
T2 - A key pathway in immune responses
AU - Procaccini, Claudio
AU - Lourenço, Elaine V.
AU - Matarese, Giuseppe
AU - La Cava, Antonio
PY - 2009
Y1 - 2009
N2 - Leptin is a hormone whose central role is to regulate endocrine functions and to control energy expenditure. After the discovery that leptin can also have pro-inflammatory effects, several studies have tried to address - at the molecular level - the pathways involved in leptin-induced modulation of the immune functions in normal and pathologic conditions. The signaling events influenced by leptin after its binding to the leptin receptor have been under scrutiny in the past few years, and considerable experimental work has elucidated the consequences of leptin effects on immune cells. This review examines the biochemistry, function and regulation of leptin signaling in view of possible intervention on this molecule for a better management and therapy of immune-mediated diseases.
AB - Leptin is a hormone whose central role is to regulate endocrine functions and to control energy expenditure. After the discovery that leptin can also have pro-inflammatory effects, several studies have tried to address - at the molecular level - the pathways involved in leptin-induced modulation of the immune functions in normal and pathologic conditions. The signaling events influenced by leptin after its binding to the leptin receptor have been under scrutiny in the past few years, and considerable experimental work has elucidated the consequences of leptin effects on immune cells. This review examines the biochemistry, function and regulation of leptin signaling in view of possible intervention on this molecule for a better management and therapy of immune-mediated diseases.
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U2 - 10.2174/157436209787048711
DO - 10.2174/157436209787048711
M3 - Article
AN - SCOPUS:65449170377
VL - 4
SP - 22
EP - 30
JO - Current Signal Transduction Therapy
JF - Current Signal Transduction Therapy
SN - 1574-3624
IS - 1
ER -