Leptin, sympathetic nervous system, and baroreflex function

Guido Grassi

Research output: Contribution to journalArticlepeer-review


In addition to its direct effects on energy metabolism and caloric intake, leptin exerts several circulatory effects that appear to be mediated by an interaction with the sympathetic nervous system and the major reflexogenic area involved in cardiovascular homeostatic control - that is, the arterial baroreflex. In this paper, the relationships between the adipocyte hormone and the neuroadrenergic function are reviewed, taking into account data collected in experimental animal models as well as in human cardiovascular (hypertension and heart failure) and noncardiovascular (obesity) diseases that are characterized by a hyperadrenergic state coupled with a hyperleptinemia.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalCurrent Hypertension Reports
Issue number3
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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