Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

Castiglioni G. Rizzo, M. C. Gilardi, V. Bettinardi, A. Savi, F. Fazio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The lesion detectability and quantification accuracy for a state-of-the-art integrated PET/CT system were investigated using Monte Carlo (MC) simulations. The 3D re-binned sinograms of true, scattered and total coincidence events were created from the simulated output list-mode data. The oncological 18F-FDG PET studies were simulated by using the MC code PET-EGS. It was observed that the recovery coefficients (RC) calculated on MC simulated realistic phantoms can be used to compensate for partial volume effect (PVE) in small neoplastic lesions in clinical studies. The results show that PET-EGS accuracy in reproducing the physical response of the considered PET/CT was >90%.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
EditorsS.D. Metzler
Pages3032-3035
Number of pages4
Volume5
Publication statusPublished - 2003
Event2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States
Duration: Oct 19 2003Oct 25 2003

Other

Other2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference
CountryUnited States
CityPortland, OR
Period10/19/0310/25/03

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

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    Rizzo, C. G., Gilardi, M. C., Bettinardi, V., Savi, A., & Fazio, F. (2003). Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations. In S. D. Metzler (Ed.), IEEE Nuclear Science Symposium Conference Record (Vol. 5, pp. 3032-3035). [M14-180]