Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

Castiglioni G. Rizzo; M. C. Gilardi; V. Bettinardi; A. Savi; F. Fazio

Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

Castiglioni G. Rizzo, M. C. Gilardi, V. Bettinardi, A. Savi, F. Fazio

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The lesion detectability and quantification accuracy for a state-of-the-art integrated PET/CT system were investigated using Monte Carlo (MC) simulations. The 3D re-binned sinograms of true, scattered and total coincidence events were created from the simulated output list-mode data. The oncological ¹⁸F-FDG PET studies were simulated by using the MC code PET-EGS. It was observed that the recovery coefficients (RC) calculated on MC simulated realistic phantoms can be used to compensate for partial volume effect (PVE) in small neoplastic lesions in clinical studies. The results show that PET-EGS accuracy in reproducing the physical response of the considered PET/CT was >90%.

Original language	English
Title of host publication	IEEE Nuclear Science Symposium Conference Record
Editors	S.D. Metzler
Pages	3032-3035
Number of pages	4
Volume	5
Publication status	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

Other

Other	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference
Country/Territory	United States
City	Portland, OR
Period	10/19/03 → 10/25/03

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Industrial and Manufacturing Engineering

Cite this

Rizzo, CG, Gilardi, MC, Bettinardi, V, Savi, A & Fazio, F 2003, Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations. in SD Metzler (ed.), IEEE Nuclear Science Symposium Conference Record. vol. 5, M14-180, pp. 3032-3035, 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference, Portland, OR, United States, 10/19/03.

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title = "Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations",

abstract = "The lesion detectability and quantification accuracy for a state-of-the-art integrated PET/CT system were investigated using Monte Carlo (MC) simulations. The 3D re-binned sinograms of true, scattered and total coincidence events were created from the simulated output list-mode data. The oncological 18F-FDG PET studies were simulated by using the MC code PET-EGS. It was observed that the recovery coefficients (RC) calculated on MC simulated realistic phantoms can be used to compensate for partial volume effect (PVE) in small neoplastic lesions in clinical studies. The results show that PET-EGS accuracy in reproducing the physical response of the considered PET/CT was >90%.",

author = "Rizzo, {Castiglioni G.} and Gilardi, {M. C.} and V. Bettinardi and A. Savi and F. Fazio",

year = "2003",

language = "English",

volume = "5",

pages = "3032--3035",

editor = "S.D. Metzler",

booktitle = "IEEE Nuclear Science Symposium Conference Record",

note = "2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference ; Conference date: 19-10-2003 Through 25-10-2003",

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TY - GEN

T1 - Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

AU - Rizzo, Castiglioni G.

AU - Gilardi, M. C.

AU - Bettinardi, V.

AU - Savi, A.

AU - Fazio, F.

PY - 2003

Y1 - 2003

N2 - The lesion detectability and quantification accuracy for a state-of-the-art integrated PET/CT system were investigated using Monte Carlo (MC) simulations. The 3D re-binned sinograms of true, scattered and total coincidence events were created from the simulated output list-mode data. The oncological 18F-FDG PET studies were simulated by using the MC code PET-EGS. It was observed that the recovery coefficients (RC) calculated on MC simulated realistic phantoms can be used to compensate for partial volume effect (PVE) in small neoplastic lesions in clinical studies. The results show that PET-EGS accuracy in reproducing the physical response of the considered PET/CT was >90%.

AB - The lesion detectability and quantification accuracy for a state-of-the-art integrated PET/CT system were investigated using Monte Carlo (MC) simulations. The 3D re-binned sinograms of true, scattered and total coincidence events were created from the simulated output list-mode data. The oncological 18F-FDG PET studies were simulated by using the MC code PET-EGS. It was observed that the recovery coefficients (RC) calculated on MC simulated realistic phantoms can be used to compensate for partial volume effect (PVE) in small neoplastic lesions in clinical studies. The results show that PET-EGS accuracy in reproducing the physical response of the considered PET/CT was >90%.

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M3 - Conference contribution

AN - SCOPUS:11944265703

VL - 5

SP - 3032

EP - 3035

BT - IEEE Nuclear Science Symposium Conference Record

A2 - Metzler, S.D.

T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference

Y2 - 19 October 2003 through 25 October 2003

ER -

Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

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