Lesion load measurements in multiple sclerosis: The effect of incorporating magnetization transfer contrast in a fast-flair sequence

Massimo Filippi; Maria A. Rocca; Giovanna Mastronardo; Giancarlo Comi

doi:10.1016/S0730-725X(98)00182-9

Lesion load measurements in multiple sclerosis: The effect of incorporating magnetization transfer contrast in a fast-flair sequence

Massimo Filippi, Maria A. Rocca, Giovanna Mastronardo, Giancarlo Comi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the ability and reproducibility of a fast fluid-attenuated inversion recovery (fast-FLAIR) sequence with and without a magnetization transfer (MT) pulse for detecting and measuring multiple sclerosis (MS)- related abnormalities on magnetic resonance imaging (MRI) scans from 20 patients. The Contrast-to-Noise ratios between lesions and normal-appearing white matter, lesion numbers, lesion volumes and the variability of such measurements were similar for the two sequences. This suggests that the addition of MT to FLAIR sequences as currently implemented on standard MRI scanners does not improve the detection of MS lesions.

Original language	English
Pages (from-to)	459-461
Number of pages	3
Journal	Magnetic Resonance Imaging
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S0730-725X(98)00182-9
Publication status	Published - Apr 1999

Keywords

Fast fluid-attenuated inversion recovery
Magnetization transfer
Multiple sclerosis

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/S0730-725X(98)00182-9

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abstract = "We compared the ability and reproducibility of a fast fluid-attenuated inversion recovery (fast-FLAIR) sequence with and without a magnetization transfer (MT) pulse for detecting and measuring multiple sclerosis (MS)- related abnormalities on magnetic resonance imaging (MRI) scans from 20 patients. The Contrast-to-Noise ratios between lesions and normal-appearing white matter, lesion numbers, lesion volumes and the variability of such measurements were similar for the two sequences. This suggests that the addition of MT to FLAIR sequences as currently implemented on standard MRI scanners does not improve the detection of MS lesions.",

keywords = "Fast fluid-attenuated inversion recovery, Magnetization transfer, Multiple sclerosis",

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AU - Comi, Giancarlo

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AB - We compared the ability and reproducibility of a fast fluid-attenuated inversion recovery (fast-FLAIR) sequence with and without a magnetization transfer (MT) pulse for detecting and measuring multiple sclerosis (MS)- related abnormalities on magnetic resonance imaging (MRI) scans from 20 patients. The Contrast-to-Noise ratios between lesions and normal-appearing white matter, lesion numbers, lesion volumes and the variability of such measurements were similar for the two sequences. This suggests that the addition of MT to FLAIR sequences as currently implemented on standard MRI scanners does not improve the detection of MS lesions.

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Lesion load measurements in multiple sclerosis: The effect of incorporating magnetization transfer contrast in a fast-flair sequence

Abstract

Keywords

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