Lesional and non-lesional epilepsies: A blurring genetic boundary

Renzo Guerrini, Elena Parrini, Alessandro Esposito, Anna Fassio, Valerio Conti

Research output: Contribution to journalReview articlepeer-review


There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies.

Original languageEnglish
JournalEuropean Journal of Paediatric Neurology
Publication statusAccepted/In press - Jan 1 2019


  • Epileptogenic structural abnormalities
  • Genetic epilepsies
  • Neurodevelopmental disorders with epilepsy
  • Phenotypic and genetic heterogeneity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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