Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids

F. Nicoletti, J. T. Wroblewski, H. Alho, C. Eva, E. Fadda, E. Costa

Research output: Contribution to journalArticle

Abstract

The stimulation of inositol phospholipid (PI) hydrolysis by excitatory amino acids was measured in the rat hippocampus or striatum after 3 different chemical or surgical lesions of putative glutamatergic pathways. Intrahippocampal infusions of kainate preferentially destroyed neurons in the CA3-4 areas, denervating the CA1 area of the ipsilateral and contralateral hippocampus. Infusions of colchicine selectively destroyed granule cells of fascia dentata, denervating the CA3 area of the ipsilateral hippocampus. Ablation of the frontal cortex selectively reduced the glutamatergic afferents to the striatum. These 3 lesions potentiated the ibotenate, glutamate and quisqualate stimulation of PI hydrolysis, while N-methyl-d-aspartate remained ineffective. This stimulation was inhibited by 2-amino-4-phosphonobutyric acid but not by phencyclidine. These lesions also increased the stimulation of PI hydrolysis elicited by norepinephrine, but failed to enhance the stimulation by carbamylcholine. These results support the hypothesis that signal transduction in a subclass of excitatory amino acid receptors present in rat brain may undergo plastic modifications following denervation.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalBrain Research
Volume436
Issue number1
DOIs
Publication statusPublished - Dec 8 1987

Fingerprint

Excitatory Amino Acids
Phosphatidylinositols
Hippocampus
Hydrolysis
Phospholipids
Quisqualic Acid
Phencyclidine
Kainic Acid
Dentate Gyrus
Colchicine
Glutamate Receptors
Carbachol
Frontal Lobe
Denervation
Aspartic Acid
Glutamic Acid
Signal Transduction
Norepinephrine
Neurons
Brain

Keywords

  • Brain lesion
  • Glutamate
  • Ibotenate
  • Inositol phospholipid hydrolysis
  • Noradrenaline

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids. / Nicoletti, F.; Wroblewski, J. T.; Alho, H.; Eva, C.; Fadda, E.; Costa, E.

In: Brain Research, Vol. 436, No. 1, 08.12.1987, p. 103-112.

Research output: Contribution to journalArticle

Nicoletti, F. ; Wroblewski, J. T. ; Alho, H. ; Eva, C. ; Fadda, E. ; Costa, E. / Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids. In: Brain Research. 1987 ; Vol. 436, No. 1. pp. 103-112.
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