Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer

Luigi Di Lauro, Patrizia Vici, Pietro Del Medico, Lucio Laudadio, Silverio Tomao, Diana Giannarelli, Laura Pizzuti, Domenico Sergi, Maddalena Barba, Marcello Maugeri-Saccà

Research output: Contribution to journalArticle

Abstract

The role of aromatase inhibitors combined with gonadotropin-releasing hormone analog in metastatic male breast cancer patients remains unknown. In this retrospective study we evaluated the activity of letrozole combined with a gonadotropin-releasing hormone analog as a first- or second-line therapy for metastatic male breast cancer patients. 19 men entered the study. We did not observe any grade 3 or 4 adverse events. 2 patients (10.5 %) had complete response, 7 patients (36.8 %) experienced a partial response, 7 patients (36.8 %) had stable disease lasting ≥6 months, and 3 patients (15.8 %) had progressive disease. Overall, the disease control rate was 84.2 %. Median progression-free survival was 12.5 months (95 % CI 8.2-16.9), median overall survival was 35.8 months (95 % CI 24.4-49.2), 1- and 2-year survival rates were 89.5 and 67 %, respectively. Interestingly, 3 out of 4 patients treated with the combination following disease progression while on aromatase inhibitor monotherapy confirmed or improved the best overall response observed in the first-line setting. The combination of letrozole and gonadotropin-releasing hormone analog is effective and safe in hormone-receptor positive, metastatic male breast cancer patients.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalBreast Cancer Research and Treatment
Volume141
Issue number1
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Endocrine therapy
  • Gonadotropin-releasing hormone analog
  • Letrozole
  • Male breast cancer
  • Metastatic disease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Di Lauro, L., Vici, P., Del Medico, P., Laudadio, L., Tomao, S., Giannarelli, D., Pizzuti, L., Sergi, D., Barba, M., & Maugeri-Saccà, M. (2013). Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer. Breast Cancer Research and Treatment, 141(1), 119-123. https://doi.org/10.1007/s10549-013-2675-y