Leucocyte migration inhibition in liver disease

C. Vergani, T. Oldoni, N. Dioguardi

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical and histologic features provide evidence that immunologic reactions of the cell mediated type are abnormal in some forms of chronic liver disease. By using the leucocyte migration test, a correlate of cellular hypersensitivity in vitro, the authors studied the production of the migration inhibitory factor by lymphocytes exposed to a fetal liver homogenate in 88 patients with acute and chronic liver disease. Abnormality of leucocyte migration was found in aggressive chronic hepatitis (inhibition in 67% of patients), cryptogenic cirrhosis (inhibition in 43%, stimulation in 13% of patients), and primary biliary cirrhosis (stimulation in 2, inhibition in 2 out of 6 patients). The results are compatible with the hypothesis that cellular immune response to liver antigens is important in the pathogenesis of such diseases.

Original languageEnglish
Pages (from-to)772-775
Number of pages4
JournalJournal of Clinical Pathology
Volume27
Issue number10
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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