Clinical and histologic features provide evidence that immunologic reactions of the cell mediated type are abnormal in some forms of chronic liver disease. By using the leucocyte migration test, a correlate of cellular hypersensitivity in vitro, the authors studied the production of the migration inhibitory factor by lymphocytes exposed to a fetal liver homogenate in 88 patients with acute and chronic liver disease. Abnormality of leucocyte migration was found in aggressive chronic hepatitis (inhibition in 67% of patients), cryptogenic cirrhosis (inhibition in 43%, stimulation in 13% of patients), and primary biliary cirrhosis (stimulation in 2, inhibition in 2 out of 6 patients). The results are compatible with the hypothesis that cellular immune response to liver antigens is important in the pathogenesis of such diseases.
|Number of pages||4|
|Journal||Journal of Clinical Pathology|
|Publication status||Published - 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine