Leukaemia relapse after allogeneic transplants for acute myeloid leukaemia: Predictive role of WT1 expression

Sarah Pozzi, Simona Geroldi, Elisabetta Tedone, Silvia Luchetti, Raffaella Grasso, Nicoletta Colombo, Carmen Di Grazia, Teresa Lamparelli, Francesca Gualandi, Adalberto Ibatici, Stefania Bregante, Maria Teresa Van Lint, Anna Maria Raiola, Alida Dominietto, Riccardo Varaldo, Alessio Signori, Andrea Bacigalupo

Research output: Contribution to journalArticle

Abstract

We assessed WT1 expression (expressed as messenger copies/104 ABL1) from marrow cells of 122 patients with acute myeloid leukaemia (AML), before and after an unmanipulated allogeneic haemopoietic stem cell transplant (HSCT). The median age was 44 years (15-69), 59% were in first remission, 74% received a myeloablative conditioning regimen and the median follow up was 865 d (34-2833). Relapse was higher in 67 patients with WT1 expression, at any time post-HSCT, exceeding 100 copies (54%), as compared to 16%, for 55 patients with post-HSCT WT1 expression

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalBritish Journal of Haematology
Volume160
Issue number4
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Acute Myeloid Leukaemia
  • Allogeneic stem cell transplantation
  • WT1

ASJC Scopus subject areas

  • Hematology

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