TY - JOUR
T1 - Leukaemic pulmonary infiltrates in adult acute myeloid leukaemia
T2 - A high-resolution computerized tomography study
AU - Potenza, Leonardo
AU - Luppi, Mario
AU - Morselli, Monica
AU - Tonelli, Stefania
AU - D'Apollo, Nicola
AU - Facchini, Luca
AU - Torricelli, Pietro
AU - Tazzioli, Giovanni
AU - Saviola, Alessia
AU - Bresciani, Paola
AU - Longo, Giuseppe
AU - Torelli, Giuseppe
PY - 2003/3
Y1 - 2003/3
N2 - Leukaemic infiltration of the lungs may occur in acute myeloid leukaemia (AML). Pulmonary infiltrates are usually microscopic and invariably associated with hyperleucocytosis. Four AML patients with respiratory symptoms and low leucocyte counts underwent standard chest radiography, bronchoscopy with bronchoalveolar lavage and high-resolution computerized tomography (HRCT) of the lungs. HRCT scans showed pulmonary infiltrates with alveolar, interstitial, mixed and peribronchial/perivascular patterns in all patients, including one with negative standard radiographic findings. Infectious agents were excluded. Histology of the lung biopsy/autopsy specimens showed leukaemic infiltrates. Pulmonary leukaemia may be the cause of pulmonary infiltrates, even in non-hyperleucocytosic AML patients with low blast counts.
AB - Leukaemic infiltration of the lungs may occur in acute myeloid leukaemia (AML). Pulmonary infiltrates are usually microscopic and invariably associated with hyperleucocytosis. Four AML patients with respiratory symptoms and low leucocyte counts underwent standard chest radiography, bronchoscopy with bronchoalveolar lavage and high-resolution computerized tomography (HRCT) of the lungs. HRCT scans showed pulmonary infiltrates with alveolar, interstitial, mixed and peribronchial/perivascular patterns in all patients, including one with negative standard radiographic findings. Infectious agents were excluded. Histology of the lung biopsy/autopsy specimens showed leukaemic infiltrates. Pulmonary leukaemia may be the cause of pulmonary infiltrates, even in non-hyperleucocytosic AML patients with low blast counts.
KW - Acute myeloid leukaemia
KW - High-resolution computerized tomography
KW - Leukaemic pulmonary infiltrates
KW - Low leucocyte count
KW - Respiratory symptoms
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U2 - 10.1046/j.1365-2141.2003.04192.x
DO - 10.1046/j.1365-2141.2003.04192.x
M3 - Article
C2 - 12648078
AN - SCOPUS:0037355340
VL - 120
SP - 1058
EP - 1061
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 6
ER -