Leukaemic pulmonary infiltrates in adult acute myeloid leukaemia: A high-resolution computerized tomography study

Leonardo Potenza, Mario Luppi, Monica Morselli, Stefania Tonelli, Nicola D'Apollo, Luca Facchini, Pietro Torricelli, Giovanni Tazzioli, Alessia Saviola, Paola Bresciani, Giuseppe Longo, Giuseppe Torelli

Research output: Contribution to journalArticlepeer-review

Abstract

Leukaemic infiltration of the lungs may occur in acute myeloid leukaemia (AML). Pulmonary infiltrates are usually microscopic and invariably associated with hyperleucocytosis. Four AML patients with respiratory symptoms and low leucocyte counts underwent standard chest radiography, bronchoscopy with bronchoalveolar lavage and high-resolution computerized tomography (HRCT) of the lungs. HRCT scans showed pulmonary infiltrates with alveolar, interstitial, mixed and peribronchial/perivascular patterns in all patients, including one with negative standard radiographic findings. Infectious agents were excluded. Histology of the lung biopsy/autopsy specimens showed leukaemic infiltrates. Pulmonary leukaemia may be the cause of pulmonary infiltrates, even in non-hyperleucocytosic AML patients with low blast counts.

Original languageEnglish
Pages (from-to)1058-1061
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number6
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Acute myeloid leukaemia
  • High-resolution computerized tomography
  • Leukaemic pulmonary infiltrates
  • Low leucocyte count
  • Respiratory symptoms

ASJC Scopus subject areas

  • Hematology

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