Leukemic cfu-aml are more sensittve than normal progenitors to genistejn-induced growth inhibition

D. Garauo, C. Carlo-Stella, E. Rggazzi, L. Mangoni, M. T. Rizzo, A. Bonajii, G. Dotri, C. Almici, V. Rizzoli

Research output: Contribution to journalArticlepeer-review

Abstract

Receptor and nonreceptor protein tyrosine kinases (PTKs) play a key rote in the control of normal and neoplastic cell growth. It was ihe aim of the present study to evaluate the effects of genistein, a natural inhibitor of PTKs, on the in vitro colony formation by normal multilineage colony-form ing units (CPU-Mix), erythroid bursts (BFU-E), granulocyte-macrophage CPU (CFU-GM), long-term culture-initiating cells (LTC-IC), and acute myelogenous leukemia CPU (CFUAML). Continuous exposure of normal marrow and blood mononuclear cells, blood CD34'CD45RA cells, and leukemic blasts to increasing doses of genistein (1-100 p,M) resulted in a statistically significant (P

Original languageEnglish
Pages (from-to)1047
Number of pages1
JournalExperimental Hematology
Volume24
Issue number9
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Fingerprint Dive into the research topics of 'Leukemic cfu-aml are more sensittve than normal progenitors to genistejn-induced growth inhibition'. Together they form a unique fingerprint.

Cite this