Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: A clue to thromboembolic risks?

Norma Maugeri, Mattia Baldini, Patrizia Rovere-Querini, Attilio Maseri, Maria Grazia Sabbadini, Angelo A. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Ischemia is a leading causes of morbidity in giant cell arteritis (GCA). We studied circulating platelets and leukocytes in patients with GCA and with polymyalgia rheumatica. Normal healthy donors (>60 a) served as controls. Patients had a significantly greater fraction of platelets expressing P-selectin, of plateletNph and plateletMo aggregates, and of Nph and Mo expressing tissue factor. These differences were correlated with the percentage of platelets expressing P-selectin and were not influenced by clinical features or by systemic inflammation. Activated circulating leukocytes and platelets could contribute to indolent vessel inflammation and possibly to thromboembolic events in patients with systemic large vessel vasculitis.

Original languageEnglish
Pages (from-to)386-388
Number of pages3
JournalAutoimmunity
Volume42
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Giant cell arteritis
  • Nphs
  • Platelets
  • Thromboembolism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: A clue to thromboembolic risks?'. Together they form a unique fingerprint.

Cite this