Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma

Roberto Molinaro, Jonathan O. Martinez, Assaf Zinger, Alessandro De Vita, Gianluca Storci, Noemi Arrighetti, Enrica De Rosa, Kelly A. Hartman, Nupur Basu, Nima Taghipour, Claudia Corbo, Ennio Tasciotti

Research output: Contribution to journalArticle

Abstract

In the last decades, several approaches were developed to design drug delivery systems to address the multiple biological barriers encountered after administration while safely delivering a payload. In this scenario, bio-inspired and bio-mimetic approaches have emerged as promising solutions to evade the mononuclear phagocytic system while simultaneously negotiating the sequential transport across the various biological barriers. Leukocytes freely circulate in the bloodstream and selectively target the inflamed vasculature in response to injury, infection, and cancer. Recently we have shown the use of biomimetic nanovesicles, called leukosomes, which combine both the physical and biological properties of liposomes and leukocytes, respectively, to selectively deliver drugs to the inflamed vasculature. Here we report the use of leukosomes to target and deliver doxorubicin, a model chemotherapeutic, to tumors in syngeneic murine models of breast cancer and melanoma. Exploiting the inflammatory pathway responsible for recruiting immune cells to the site of injury, leukosomes exhibited increased targeting of cancer vasculature and stroma. Furthermore, delivery of doxorubicin with leukosomes enabled significant tumor growth inhibition compared with free doxorubicin in both breast and melanoma tumors. This study demonstrates the promise of using biomimetic nanovesicles for effective cancer management in solid tumors.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalBiomaterials Science
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2020

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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    Molinaro, R., Martinez, J. O., Zinger, A., De Vita, A., Storci, G., Arrighetti, N., De Rosa, E., Hartman, K. A., Basu, N., Taghipour, N., Corbo, C., & Tasciotti, E. (2020). Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma. Biomaterials Science, 8(1), 333-341. https://doi.org/10.1039/c9bm01766f