Leukocyte-poor PRP application for the treatment of knee osteoarthritis

Giuseppe Filardo, Elizaveta Kon, Berardo Di Matteo, Alessandro Di Martino, Andrea Sessa, Maria Letizia Merli, Maurilio Marcacci

Research output: Contribution to journalArticlepeer-review


Purpose: the aim of this study was to describe the clinical results obtained after intra-articular injection of a leukocyte-poor platelet-rich plasma (PRP) preparation for the treatment of knee osteoarthritis (OA). Methods: forty-five patients (mean age: 59 years, mean BMI: 27) were included and treated with a cycle of three weekly injections of autologous conditioned plasma. Six patients were affected by bilateral symptomatic OA, therefore 51 knees in total were treated. The patients were divided into two groups: those affected by early/moderate OA and those affected by severe OA. The patients were submitted to baseline evaluation and evaluation after a mean follow-up of 14.5 months (range: 6-24 months), performed using the following outcome measures: IKDC-subjective, EQ-VAS, Tegner, and KOOS scores. Adverse events and patient satisfaction were also recorded. The results in the two groups of patients (“early/moderate” vs “severe OA”) were analyzed separately. Results: the overall clinical outcome was positive and the treatment proved to be safe. In the “early/moderate OA” group, the IKDC-subjective score increased from 36.4 at the baseline evaluation to 57.3 at the follow- up (p

Original languageEnglish
Pages (from-to)112-120
Number of pages9
Issue number3
Publication statusPublished - Jul 1 2013


  • Growth factors
  • Injections
  • Knee
  • Osteoarthritis
  • PRP

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Surgery


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