Leukocyte redistribution: Effects of beta blockers in patients with chronic heart failure

Stephan von Haehling, Joerg C. Schefold, Ewa Jankowska, Wolfram Doehner, Jochen Springer, Kristin Strohschein, Sabine Genth-Zotz, Hans Dieter Volk, Philip Poole-Wilson, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Overproduction of pro-inflammatory cytokines is a well established factor in the progression of chronic heart failure (CHF). Changes in cellular immunity have not been widely studied, and the impact of standard medication is uncertain. Here we investigate whether a leukocyte redistribution occurs in CHF and whether this effect is influenced by beta-blocker therapy. Methodology: We prospectively studied 75 patients with systolic CHF (age: 68±11 years, left ventricular ejection fraction 32±11%, New York Heart Association class 2.5±0.7) and 20 age-matched healthy control subjects (age: 63±10 years). We measured the response of cells to endotoxin exposure in vitro, analysed subsets of lymphocytes using flow cytometry, and assessed plasma levels of the pro-inflammatory markers interleukin 1, 6, tumor necrosis factor-α, and soluble tumor necrosis factor receptors 1 and 2. Principal findings: While no differences in the number of leukocytes were noted between patients with CHF and healthy controls, we detected relative lymphopenia in patients with CHF (p

Original languageEnglish
Article numbere6411
JournalPLoS One
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 29 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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