Leukocyte response in patients suffering from acute stroke

Francesco Violi, Maurizia Rasura, Cesare Alessandri, Domenico Intiso, Massimo Germani, Marco Servi, Cesare Fieschi, Francesco Balsano

Research output: Contribution to journalArticlepeer-review


The oxidation of adrenaline to adrenochrome has been shown to reflect the activation of leukocytes in vivo. We tested the in vivo activation of leukocytes by measuring plasma oxidation of adrenaline to adrenochrome in patients suffering from cerebral ischemia, cerebral hemorrhage, and transient ischemic attacks and in healthy subjects. Patients with cerebral ischemia and cerebral hemorrhage had significantly higher values than healthy subjects, while patients with transient ischemic attacks had values similar to those of healthy subjects. In some patients with cerebral ischemia, the test was repeated 4 and 15 days after the acute event, but the follow-up data did not differ from baseline values. Our study shows that leukocyte activation occurs in cerebral ischemia and cerebral hemorrhage.

Original languageEnglish
Pages (from-to)1283-1284
Number of pages2
Issue number10
Publication statusPublished - 1988


  • Cerebrovascular disorders
  • Free radicals
  • Leukocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)


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