Leukocyte traffic control: A novel therapeutic strategy for inflammatory bowel disease - An update

Monica Cesarini, Gionata Fiorino

Research output: Contribution to journalArticle

Abstract

Adhesion molecules play a key role in the pathogenetic mechanisms of inflammatory bowel disease (IBD), both in Crohn's disease (CD) and ulcerative colitis (UC). In the last decade, some progress has been made in understanding their key role in leukocyte trafficking control in terms of basic research, but evidence of clinical efficacy is lacking. In the last 2 years, new molecules directed against integrins and integrin receptors have been developed and investigated in clinical trials, showing that anti-α4β7 integrin agents can be effective and safe for the induction and maintenance of remission in active CD and UC. Preliminary data show that anti-MAdCAM, anti-β7 and anti-integrin receptor agents are not all effective in IBD. Such results open new perspectives on clinical management of IBD, and new directions in understanding the role of adhesion molecules and leukocyte recruitment both in CD and UC.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalExpert Review of Clinical Immunology
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • anti-integrins
  • antiadhesion molecules
  • Crohn's disease
  • inflammatory bowel disease
  • leukocyte recruitment
  • ulcerative colitis
  • vedolizumab

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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