Abstract
There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Whether it is a risk factor for recurrent thrombosis too is currently unknown. In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis. The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model. Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 109/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged
| Original language | English |
|---|---|
| Pages (from-to) | 97-100 |
| Number of pages | 4 |
| Journal | American Journal of Hematology |
| Volume | 85 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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ASJC Scopus subject areas
- Hematology
Cite this
Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia. / De Stefano, Valerio; Za, Tommaso; Rossi, Elena; Vannucchi, Alessandro M.; Ruggeri, Marco; Elli, Elena; Micó, Caterina; Tieghi, Alessia; Cacciola, Rossella R.; Santoro, Cristina; Gerli, Giancarla; Guglielmelli, Paola; Pieri, Lisa; Scognamiglio, Francesca; Rodeghiero, Francesco; Pogliani, Enrico M.; Finazzi, Guido; Gugliotta, Luigi; Leone, Giuseppe; Barbui, Tiziano.
In: American Journal of Hematology, Vol. 85, No. 2, 02.2010, p. 97-100.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia
AU - De Stefano, Valerio
AU - Za, Tommaso
AU - Rossi, Elena
AU - Vannucchi, Alessandro M.
AU - Ruggeri, Marco
AU - Elli, Elena
AU - Micó, Caterina
AU - Tieghi, Alessia
AU - Cacciola, Rossella R.
AU - Santoro, Cristina
AU - Gerli, Giancarla
AU - Guglielmelli, Paola
AU - Pieri, Lisa
AU - Scognamiglio, Francesca
AU - Rodeghiero, Francesco
AU - Pogliani, Enrico M.
AU - Finazzi, Guido
AU - Gugliotta, Luigi
AU - Leone, Giuseppe
AU - Barbui, Tiziano
PY - 2010/2
Y1 - 2010/2
N2 - There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Whether it is a risk factor for recurrent thrombosis too is currently unknown. In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis. The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model. Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 109/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged
AB - There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Whether it is a risk factor for recurrent thrombosis too is currently unknown. In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis. The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model. Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 109/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged
UR - http://www.scopus.com/inward/record.url?scp=75449098063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75449098063&partnerID=8YFLogxK
U2 - 10.1002/ajh.21593
DO - 10.1002/ajh.21593
M3 - Article
C2 - 20052743
AN - SCOPUS:75449098063
VL - 85
SP - 97
EP - 100
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 2
ER -